N-브로모숙신산이미드
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N-브로모숙신산이미드 속성
- 녹는점
- 175-180 °C (dec.)(lit.)
- 끓는 점
- 221.4°C (rough estimate)
- 밀도
- 2.098
- 증기압
- 14.8 hPa (20 °C)
- 굴절률
- 1.6060 (estimate)
- 저장 조건
- Store at +2°C to +8°C.
- 용해도
- 14.8g/l(분해)
- 산도 계수 (pKa)
- -2.78±0.20(Predicted)
- 물리적 상태
- 결정성 분말
- 색상
- 흰색에서 밝은 노란색
- 냄새
- 브롬 특유의 냄새
- 수용성
- 아세톤, 테트라히드로푸란, 디메틸 포름아미드, 디메틸 설폭사이드 및 아세토니트릴에 용해됩니다. 물과 아세트산에 약간 용해됩니다. 에테르, 헥산 및 사염화탄소에 불용성.
- 감도
- Moisture Sensitive
- Merck
- 14,1438
- BRN
- 113916
- 안정성
- 안정적인. 강한 산화제, 할로겐화 탄화수소와 호환되지 않습니다.
- InChIKey
- PCLIMKBDDGJMGD-UHFFFAOYSA-N
- LogP
- -1.19
- CAS 데이터베이스
- 128-08-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | C,Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-34-36/37/38 | ||
| 안전지침서 | 26-36/37/39-45-37/39 | ||
| 유엔번호(UN No.) | UN 3261 8/PG 2 | ||
| WGK 독일 | 3 | ||
| 위험 참고 사항 | Harmful | ||
| TSCA | Yes | ||
| 위험 등급 | 8 | ||
| 포장분류 | III | ||
| HS 번호 | 29251995 | ||
| 유해 물질 데이터 | 128-08-5(Hazardous Substances Data) | ||
| 독성 | LD50 orally in Rabbit: > 2000 mg/kg | ||
| 기존화학 물질 | KE-03714 |
N-브로모숙신산이미드 C화학적 특성, 용도, 생산
화학적 성질
white to light yellow crystalline powder용도
N-Bromosuccinimide is a brominated succinimide used as a chemical reagent in radical substitution and electrophilic addition reactions in organic synthesis. In bromination of olefins; in oxidation of alcohols to aldehydes and ketones and of aldehydes to acid bromides.정의
ChEBI: N-bromosuccinimide is a five-membered cyclic dicarboximide compound having a bromo substituent on the nitrogen atom. It has a role as a reagent. It is a dicarboximide, a pyrrolidinone and an organobromine compound. It is functionally related to a succinimide.제조 방법
N-Bromosuccinimide is prepared by addition of bromine to a cold aqueous solution of succinimide or by reaction of succinimide with NaBrO2 in the presence of HBr.
1.62mol (160g) succinimide is dissolved in a mixture of 1.60mol (64g) NaOH, 300g crushed ice and 400ml water. Cool the mixture in an ice bath, and add 85ml (1.65 mol, 264g) Br2 at once while stirring violently. Stir for two more minutes, then filter the precipitated product and wash with ice water. Dry in a desiccator. Yield 75-81%.
Don't clean up NBS too much, the stinky yellow stuff still containing a bit of Br2 works best. N-Bromosuccinimide is a brominating agent that replaces hydrogen atoms in benzylic or allylic positions. It is used in the oxidation of secondary alcohols to ketones and in controlled low-energy brominations.
Safety Profile
Poison by intraperitoneal route. An irritating poison to skin, eyes, and mucous membranes. Reacts explosively with adme, dtallyl sulfide, and hydrazine hydrate. Explosive reaction with propiononitrile after heating to 105℃ for 24 hours. Violent reaction with dtbenzoyl peroxide + 4-tok acid. When heated to decomposition it emits toxic fumes of Brand NOx. See also BROMIDES and NITROGEN MONOXIDE.Purification Methods
N-Bromosuccinimide (30g) is purified by dissolving rapidly in 300mL of boiling water and filtering through a fluted filter paper into a flask immersed in an ice bath, and left for 2hours. The crystals are filtered off, washed thoroughly with ca 100mL of ice-cold water and drained on a Büchner funnel before drying under vacuun over P2O5 or CaCl2 [Dauben & McCoy J Am Chem Soc 81 4863 1959]. This brominating agent has also been crystallised from acetic acid or water (10 parts), washed in water and dried in vacuo [Wilcox et al. J Am Chem Soc 108 7693 1986, Shell et al. J Am Chem Soc 108 121 1986, Phillips & Cohen J Am Chem Soc 108 2013 1986, Beilstein 21/9 V 543.]N-브로모숙신산이미드 준비 용품 및 원자재
원자재
준비 용품
5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
5-Bromo-2-oxindole
BISPYRAZOLONE
2-Amino-5-bromopyrazine
Raltitrexed
METHYL 3-((PYRROLIDIN-1-YL)METHYL)BENZOATE
4-CHLORO-3-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE
3-BROMO-1-(TRIISOPROPYLSILYL)INDOLE
5-BROMO-2-CHLORO-4,6-DIMETHYLNICOTINONITRILE
2,6-Dibromopyridin-3-amine
5-BROMO-6-HYDROXY-1H-PYRIMIDINE-2,4-DIONE
Ethyl 4-bromocrotonate
5-Bromo-4-chloro-2-(methylthio)-7H-pyrrolo[2,3-D]pyrimidine ,97%
2-Hydroxy-5-bromopyridine
3-Nitrobenzyl bromide
2,1,3-BENZOTHIADIAZOL-4-YLMETHANOL,97%
2-NAPHTHALEN-1-YL-ETHYLAMINE
METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE
5-BROMO-2-(PIPERIDIN-1-YL)PYRIMIDINE
Methyl 3-(morpholinomethyl)benzoate ,98%
2-(Bromomethyl)pyridine hydrobromide
6-BROMOMETHYL-2-PYRIDINECARBOXYLIC ACID
alpha,alpha'-Dibromo-p-xylene
METHYL ALPHA-BROMOPHENYLACETATE
IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID
Methyl 2-bromomethylbenzoate
Bromoacetonitrile
4-피라졸카르복시산
4-AMINO-N,N-DIMETHYLBENZYLAMINE
8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE
1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE
4-Bromo-2-methoxyphenol
3-(BROMOMETHYL)BENZOIC ACID
3-BROMO-5-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE
DIETHYL 2-(ACETAMIDO)-2-(2-(BROMOMETHYL)-5-NITROBENZYL)MALONATE
4-BROMO-5-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID
IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
5-BROMO-4,6-DIMETHOXYPYRIMIDINE
2,5-DICHLOROTHIOPHENE-3-CARBOXYLIC ACID
5-BROMO-2-(MORPHOLIN-4-YL)PYRIMIDINE
N-브로모숙신산이미드 공급 업체
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