LD50 in various strains of mice, rats (mg/kg): 795-1673, 200-720 orally; 506-811, 265-575 i.p. (Bolte)
그림문자(GHS):
신호 어:
Danger
유해·위험 문구:
암호
유해·위험 문구
위험 등급
범주
신호 어
그림 문자
P- 코드
H301
삼키면 유독함
급성 독성 물질 - 경구
구분 3
위험
P264, P270, P301+P310, P321, P330,P405, P501
예방조치문구:
NFPA 704
0
3
0
Fenbufen C화학적 특성, 용도, 생산
개요
Fenbufen has been found to be an effective, well-tolerated drug for the treatment of
rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Fenbufen is prepared by the Friedel-Crafts (aluminum chloride – nitrobenzene)
acylation of biphenyl with succinic anhydride. The compound is metabolized
in humans first to 4-hydroxy-4-biphenylbutyric
acid (tmax 2.5 h) then to 4-biphenyl acetic acid
(tmax 7.5 h). Both metabolites are more active
than fenbufen itself and circulate for several
hours (t1/2 10 h). This slow conversion of fenbufen to active metabolites having relatively
long plasma half-lives allows for once a day dosing with this agent.
Fenbufen belongs to the class of non-steroidal anti-inflammatory drugs, widely used as an antipyretic and analgesic in medical applications. Its mode of action involves the inhibition of cyclooxygenase enzyme and thereby prevents the synthesis of certain prostaglandins.
Safety Profile
Poison by ingestion,intraperitoneal, and subcutaneous routes. Human systemiceffects by ingestion: cough, sweating, body temperature.An experimental teratogen. Other experimentalreproductive effects. An anti-inflammatory agent. Whenheated to decomposi
