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PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-

PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]- 구조식 이미지

카스 번호:: 1638-41-1

상품명:: PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-

동의어(영문):: p38 MAPK Inhibitor IV;p38 MAP Kinase Inhibitor IV;p38 MAP Kinase Inhibitor IV (B10);2,2'-Sulfonylbis(3,4,6-trichlorophenol);PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-;p38 MAP Kinase Inhibitor IV,p-38 MAP Kinase Inhibitor IV;p38 MAP Kinase Inhibitor IV - CAS 1638-41-1 - Calbiochem;Phenol, 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)sulfonyl]-

CBNumber:: CB22446185

분자식:: C12H4Cl6O4S

포뮬러 무게:: 456.94

MOL 파일:: 1638-41-1.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 33

PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]- 속성

녹는점: 244-245 °C(Solv: ethyl acetate (141-78-6))

끓는 점: 590.0±50.0 °C(Predicted)

밀도: 1.854±0.06 g/cm3(Predicted)

저장 조건: 2-8°C

용해도: DMSO: 용해성5mg/mL, 투명(가온)

물리적 상태: 가루

산도 계수 (pKa): 2.43±0.50(Predicted)

색상: 흰색에서 베이지색

안전

WGK 독일	3

PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]- C화학적 특성, 용도, 생산

용도

p38 MAP Kinase Inhibitor IV is an ATP-competitive p38α/β MAPK inhibitor.

일반 설명

A cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC₅₀ = 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 μM) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM respective inhibitor).

Biochem/physiol Actions

p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK with IC50 values of 130 nM for p38α and 550 nM for p38β. It is much less active with ≤23% inhibition at 1 μM against p38γ/σ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203580 in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM inhibitor). A recent study showed that p38 MAP Kinase Inhibitor IV could consistently and significantly enhance reprogramming and iPS cell generation from somatic cells.

PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]- 준비 용품 및 원자재

원자재

준비 용품

PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]- 공급 업체

글로벌( 33)공급 업체

공급자	전화	이메일	국가	제품 수	이점
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Chemwill Asia Co.,Ltd.	86-21-51086038	chemwill_asia@126.com	CHINA	23931	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Pharmacodia (Beijing) Co.,Ltd	+86-400-851-9921	sales@pharmacodia.com	China	2317	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58
Novachemistry	44-20819178-90 02081917890	info@novachemistry.com	United Kingdom	4381	58

PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]- 관련 검색:

2,2''-티오비스(4,6-디클로로페놀) 2,2''-티오비스(4-클로로페놀) 4-Nitrobenzenesulfonyl chloride Dichlorophen 1,3-dichloro-5-(methylsulphonyl)benzene 2,3-DICHLOROTHIOPHENOL 3,5-DICHLOROTHIOANISOLE 2-(METHYLSULFONYL)PHENOL BITHIONOL SULFOXIDE 4-CHLORO-2-[(5-CHLORO-2-HYDROXYPHENYL)SULFONYL]PHENOL 1,4-DICHLORO-2-(METHYLSULFONYL)BENZENE PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-