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암피실린 무수산염

암피실린 무수산염
암피실린 무수산염 구조식 이미지
카스 번호:
69-53-4
한글명:
암피실린 무수산염
동의어(한글):
암피실린무수산염;암피실린무수산염
상품명:
Ampicillin
동의어(영문):
Ampicillin Sulbactam;Nonane-1,9-diamine;Wymox;Unasyn;penbritin;principen;polycillin;aminobenzylpenicillin;p-50;ab-pc
CBNumber:
CB2247346
분자식:
C16H19N3O4S
포뮬러 무게:
349.4
MOL 파일:
69-53-4.mol

암피실린 무수산염 속성

녹는점
198-200 °C (dec.)(lit.)
알파
D23 +287.9° (c = 1 in water)
끓는 점
201.8°C (rough estimate)
밀도
1.2794 (rough estimate)
굴절률
1.6320 (estimate)
저장 조건
2-8°C
용해도
NH4OH 1 M: 50 mg/mL, clear, colorless
물리적 상태
solid
색상
White to Pale Yellow
산도 계수 (pKa)
2.5 (COOH)(at 25℃)
수용성
13.9g/L(25 ºC)
JECFA Number
85
Merck
13,591
BRN
1090925
안정성
Stable, but may be moisture sensitive. Incopmpatible with strong oxidizing agents.
InChIKey
AVKUERGKIZMTKX-NJBDSQKTSA-N
CAS 데이터베이스
69-53-4(CAS DataBase Reference)
IARC
3 (Vol. 50) 1990
EPA
Ampicillin (69-53-4)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,T
위험 카페고리 넘버 36/37/38-42/43-61
안전지침서 22-26-36/37-45-53
WGK 독일 2
RTECS 번호 XH8425000
F 고인화성물질 10-23
HS 번호 29212900
유해 물질 데이터 69-53-4(Hazardous Substances Data)
독성 LD50 oral in mouse: > 5gm/kg
기존화학 물질 KE-01538
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 흡입 시 알레르기성 반응, 천식 또는 호흡 곤란 등을 일으킬 수 있음 호흡기 과민성 물질 구분 1 위험 P261, P285, P304+P341, P342+P311,P501
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P272 작업장 밖으로 오염된 의복을 반출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P284 호흡 보호구를 착용하시오.
P302+P352 피부에 묻으면 다량의 물로 씻으시오.
P333+P313 피부자극성 또는 홍반이 나타나면 의학적인 조치·조언를 구하시오.

암피실린 무수산염 MSDS


Ampicillin

암피실린 무수산염 C화학적 특성, 용도, 생산

개요

Ampicillin is an antibacterial antibiotic from the α-aminobenzyl penicillin group, which differs from penicillin by the presence of an amino group that facilitates penetration through the outer membrane of some gram-negative bacteria.
Ampicillin is Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. Ampicillin acts by interfering directly with the biosynthesis of peptidoglycan, which constitutes the major component of the bacterial cell wall, leading to structural instability and death of bacteria.
Ampicillin is a β-lactam antibiotic within the penicillin family. As a member of this family, Ampicillin is susceptible to β-lactamase, which hydrolyzes the β-lactam ring. This broad spectrum antibiotic is effective against gram-positive, gram-negative bacteria and anaerobic bacteria. Ampicillin is widely used in cell culture as a selective agent. As an antibiotic, Ampicillin binds to penicillin binding proteins (PBPs) on a susceptible organism and Inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. After binding to the PBPs, Ampicilin acts as a structural analogue of acyl-D-alanyl-D-alanine, acylates the transpeptidase enzyme and thereby prevents the cross-linking of the peptidoglycan of the cell wall necessary for the growth of the bacterium.
Ampicillin sodium can be used as a selective agent in several types of isolation media. Ampicillin sodium is routinely used to select for cells containing the pcDNA3.1 and pEAK10 resistance plasmids in cell line A904L at an effective concentration of 50 μg/ml.

화학적 성질

Ampicillin in anhydrous form occurs as crystals.

용도

Labelled Ampicillin. Orally active, semi-synthetic antibiotic; structurally related to penicillin. Antibacterial.

정의

ChEBI: A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.

색상 색인 번호

Ampicillin caused contact dermatitis in a nurse also sensitized to amoxicillin (with tolerance to oral phenoxymethylpenicillin) and in a pharmaceutical factory worker. Systemic drug reactions are common. Crossreactivity is regular with ampicillin and can occur with other penicillins.

Safety Profile

Poison by intracerebral route. Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: fever, agranulocytosis, and other blood effects. An experimental teratogen. Mutation data reported. Questionable carcinogen. When heated to decomposition it emits very toxic fumes of NO, and SOx,.

잠재적 노출

Used as an antibiotic.

운송 방법

UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

비 호환성

May be incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

폐기물 처리

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

암피실린 무수산염 준비 용품 및 원자재

원자재

준비 용품


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