ChemicalBook >제품 카탈로그 >생화학 공학>억제제>PI3K / Akt / mTOR>PDK-1 억제제>OSU-03012

OSU-03012

OSU-03012 구조식 이미지

카스 번호:: 742112-33-0

상품명:: OSU-03012

동의어(영문):: AR-12;CS-1848;N/AAR-12;OSU-03012;OSU-03012, >=98%;OSU-03012 (AR-12);OSU-03012 USP/EP/BP;N/AAR-12; OSU03012; OSU 03012;OSU-03012 (AR-12);N/AAR-12; OSU03012; OSU 03012;2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide

CBNumber:: CB22501006

분자식:: C26H19F3N4O

포뮬러 무게:: 460.45

MOL 파일:: 742112-33-0.mol

속성

안전

용도

공급 업체 125

OSU-03012 속성

저장 조건: Store at -20°C

용해도: ≥23 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

물리적 상태: 고체

물리적 상태: 단단한 모양

CAS 데이터베이스: 742112-33-0

안전

OSU-03012 C화학적 특성, 용도, 생산

개요

Cyclooxygenase-2 (COX-2) appears to play a significant role in the development and progression of cancer and COX-2 inhibitors such as celecoxib exhibit anti-cancer activity. OSU03012 is an analog of celecoxib that exhibits anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase/Akt pathway. It has an IC₅₀ value of 5 μM for inhibition of 3-phosphoinositide-dependent kinase-1, and therefore Akt activation, with no measurable COX-2 inhibition up to 50 μM. OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 μM across a panel of 60 cancer cell lines. It does not inhibit signal transduction through the mitogen-activated protein kinase (MAPK) pathway. OSU03012 induces apoptosis of chronic lymphocytic leukemia cells independent of bcl-2 overexpression using both caspase-dependent and independent pathways.

용도

OSU 03012 is a PDK1 inhibitor and inducer of caspase and p53-independent apoptosis, also used in the development of anticancer agents by modification of novel immunosuppressant FTY720 and PDK1 inhibitor OSU-03012, compound for treating Alzheimers diseases.

정의

ChEBI: A member of the class of pyrazoles that is N-[4-(pyrazol-1-yl)phenyl]glycinamide in which the pyrazole ring is substituted at positions 3 and 5 by trifluoromethyl and phenanthrene-2-yl groups respectively.

OSU-03012 준비 용품 및 원자재

원자재

준비 용품

OSU-03012 공급 업체

글로벌( 125)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58

OSU-03012 관련 검색:

(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride 2-Amino-3-bromo-6-chloropyrazine 2-AMino-6-broMo-5,6-dihydro-7(4H)-benzothiazolone 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER L-Alanyl-L-Glutamine impurity 25 2-AMino-4-chloro-6-MethylpyriMidine-5-carbonitrile 1H-Imidazole-4-carboxylicacid,2-amino-,ethylester(9CI) Sildenafil citrate BX-912 Axitinib Dasatinib BX-795 BEZ235 (NVP-BEZ235, Dactolisib)