LDN-193189
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LDN-193189 속성
- 밀도
- 1.33
- 저장 조건
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- 용해도
- H2O: 용해성5mg/mL, 투명(따뜻한)
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 8.79±0.10(Predicted)
- 색상
- 노란색에서 주황색으로
- InChIKey
- XHBVYDAKJHETMP-UHFFFAOYSA-N
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| WGK 독일 | 3 | ||
|---|---|---|---|
| HS 번호 | 29339900 |
| 그림문자(GHS): |
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| 신호 어: | Warning | |||||||||||||||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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LDN-193189 C화학적 특성, 용도, 생산
개요
Normal development and tissue repair are controlled in part by SMADs, a family of intracellular proteins that are activated by signaling via serine/threonine kinase receptors of the TGF-용도
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline, is a selective inhibitor of bone morphogenetic protein (BMP) pathway, useful in the treatment of diseases. Potent BMP Inhibitor?, Promotes hPSC Neural Induction?.Biochem/physiol Actions
Although LDN193189 is a structural analog of dorsomorphin, these two drugs are found to establish different cellular responses. In vitro analysis reveals that LDN193189 inhibits a number of intracellular kinases such as, mitogen activated protein kinase 14 and 8 ( p38and c-Jun N-terminal kinase respectively), as well as those associated with AKT (serine/threonine kinase) and mTOR (mammalian target of rapamycin) signaling mechanisms. LDN193189 is known to elevate the levels hemoglobin and thus helps to prevent the onset of anemia of inflammation.LDN-193189 준비 용품 및 원자재
원자재
4-(quinolin-4-yl)-1H-pyrazol-5-aMine
4-quinolylmethanol
4-Chloromethylquinoline
2-(quinolin-4-yl)acetonitrile
4-Quinolinecarboxaldehyde
준비 용품
LDN-193189 공급 업체
글로벌( 155)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29271 | 58 |