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NFPA 704
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2
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Dexrazoxane C화학적 특성, 용도, 생산
개요
Dexrazoxane is the dextro-isomer of razoxane approved as a protectant against the
cardiotoxicity of doxorubicin in breast cancer patients. This agent does not alter the
anticancer effect of doxorubicin. Its mode of action suggests a chelation of free
radicals. In mice, dexrazoxane also offers protection against cardiac side effects of
epirubicin, but not mitoxantrone.
용도
Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.
일반 설명
Dexrazoxane is a member of bis(2,6-dioxopiperazines), that functions as a topoisomerase 2 catalytic inhibitor. Dexrazoxane is a free radical scavenger. It might protect the heart from doxorubicin-associated damage. Dexrazoxane acts as a cardiopulmonary protectant, while treating Hodgkin′s disease (HD). It functions as a chelating agent, which limits the formation of anthracycline-iron complexes. It is used to synthesize antimalarial drugs.
생물학적 활성
Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.
