PF-4708671
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PF-4708671 속성
- 끓는 점
- 572.8±50.0 °C(Predicted)
- 밀도
- 1.348±0.06 g/cm3(Predicted)
- 저장 조건
- room temp
- 용해도
- DMSO: ≥20mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 10.20±0.10(Predicted)
- 색상
- 회백색
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
PF-4708671 C화학적 특성, 용도, 생산
화학적 성질
Pale purple Solid용도
PF-4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). PF-4708671 inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect on highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases.효소 저해제
This cell-permeable protein kinase inhibitor (FW = 390.41 g/mol; CAS 1255517-76-0; Solubility = 30 mg/mL DMSO, <1 mg/mL H2O) targets p70 ribosomal S6 kinase (S6K1 isoform) with Ki of 20 nM and IC50 of 160 nM, without significant inhibition of S6K2 isoform or Akt1, Akt2, PKA, PKCα, PKC?, PRK2, ROCK2, RSK1, RSK2, or SGK1. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMAinduced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases.PF-4708671 준비 용품 및 원자재
원자재
준비 용품
PF-4708671 공급 업체
글로벌( 129)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 967 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29271 | 58 |
Chemia Biotechnology(Shanghai) Co., Ltd | +8613816753574 |
info@chemia-pharm.com | CHINA | 311 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10523 | 58 |