ChemicalBook >제품 카탈로그 >6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone 구조식 이미지

카스 번호:: 64232-83-3

상품명:: 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

동의어(영문):: L189;L 189;L189;(E)-6-amino-5-(benzylideneamino)-2-mercaptopyrimidin-4-ol;6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone;6-Amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one;6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone;4(1H)-PyriMidinone, 6-aMino-2,3-dihydro-5-[(phenylMethylene)aMino]-2-thioxo-

CBNumber:: CB22518932

분자식:: C11H10N4OS

포뮬러 무게:: 246.29

MOL 파일:: 64232-83-3.mol

속성

안전

용도

공급 업체 86

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone 속성

녹는점: 250 °C (decomp)

밀도: 1.45±0.1 g/cm3(Predicted)

저장 조건: Keep in dark place,Inert atmosphere,2-8°C

용해도: ≥62.5 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 8.16±0.60(Predicted)

안전

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone C화학적 특성, 용도, 생산

개요

L189 is a competitive inhibitor of DNA ligases I, III, and IV (IC₅₀s = 5, 9, and 5 μM, respectively). It blocks DNA binding (K_i = 5 μM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation. L189 preferentially inhibits the interaction of the ligase with damaged DNA, inhibiting base excision repair and non-homologous end-joining.

용도

L189 has been shown to inhibit DNA ligases I, III, and IV and may have potential use in the development of anticancer agents.

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone 준비 용품 및 원자재

원자재

준비 용품

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone 공급 업체

글로벌( 86)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Chemia Biotechnology（Shanghai） Co., Ltd	+8613816753574	info@chemia-pharm.com	CHINA	311	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69