MK8245
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MK8245 속성
- 끓는 점
- 698.3±65.0 °C(Predicted)
- 밀도
- 1.82
- 저장 조건
- Sealed in dry,Store in freezer, under -20°C
- 용해도
- ≥23.35 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 2.85±0.10(Predicted)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
그림문자(GHS): | |||||||||||||||
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신호 어: | Danger | ||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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MK8245 C화학적 특성, 용도, 생산
개요
MK-8245 is a liver-targeted inhibitor of stearoyl-CoA desaturase (SCD; IC50s = 3, 3, and 1 nM for rat, mouse, and human SCD1, respectively). It is selective for SCD1 over Δ5- and Δ6-desaturases (IC50s = >100,000 nM). MK-8245 (20-60 mg/kg) reduces the hepatic, but not Harderian gland, ratio of oleic acid to stearic acid, a marker of chronic SCD activity, and blood glucose levels, without inducing the formation of skin lesions or eye squinting behavior, in a mouse model of high-fat diet-induced obesity. It also inhibits hepatitis C virus (HCV) replication without inducing cytotoxicity in LucNeo2 cells (IC50 = 39.8 nM).용도
This product is Informer compound X9 of the Aryl Halide Chemistry Informer Library developed by chemists at Merck & Co., Inc., Kenilworth, NJ, U.S., which contains 18 drug-like molecules representative of those encountered in complex synthesis. By screening a new reaction against the Informer Library, chemists can directly compare and analyse a reaction′s successes and shortcomings among different methods and various research teams. It may also be used to facilitate deeper method development for performance or utility.MK8245 준비 용품 및 원자재
원자재
3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazole-5-carbonitrile
3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazole-5-carboxamide
tert-butyl2-(5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetate
3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)-4,5-dihydroisoxazole-5-carboxamide
4-(2-Bromo-5-fluorophenoxy)-1-[5-(2H-tetrazol-5-yl)-3-isoxazolyl]piperidine
Piperidine, 4-(2-bromo-5-fluorophenoxy)-
2-Bromo-5-fluorophenol
4-Hydroxypiperidine
N-BOC-4-Hydroxypiperidine
1-브로모-2,4-디플로로벤젠
에틸브로모아세트산
준비 용품
MK8245 공급 업체
글로벌( 83)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29831 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 24738 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8475 | 58 |
Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 132020 | 58 |
Shanghai Boyle Chemical Co., Ltd. | |
sales@boylechem.com | China | 2923 | 55 |