말로노니트릴
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말로노니트릴 속성
- 녹는점
- 30-32 °C (lit.)
- 끓는 점
- 220 °C (lit.)
- 밀도
- 1.049 g/mL at 25 °C (lit.)
- 증기압
- 1 hPa (50 °C)
- 굴절률
- 1.4150
- 인화점
- 234 °F
- 저장 조건
- 2-8°C
- 용해도
- 133g/l
- 산도 계수 (pKa)
- 11(at 25℃)
- 물리적 상태
- 결정질 저융점 질량
- 색상
- 흰색에서 황갈색
- Specific Gravity
- 1.049
- 수소이온지수(pH)
- pH : 4.5
- 수용성
- 13.3g/100mL(20℃)
- Merck
- 14,5711
- BRN
- 773697
- 노출 한도
- TLV-TWA 8 mg/m3 (3 ppm) (NIOSH).
- Dielectric constant
- 46.0
- InChIKey
- CUONGYYJJVDODC-UHFFFAOYSA-N
- CAS 데이터베이스
- 109-77-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,N | ||
---|---|---|---|
위험 카페고리 넘버 | 23/24/25-50/53 | ||
안전지침서 | 23-27-45-60-61 | ||
유엔번호(UN No.) | UN 2647 6.1/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | OO3150000 | ||
F 고인화성물질 | 8 | ||
자연 발화 온도 | 365 °C | ||
TSCA | Yes | ||
위험 등급 | 6.1 | ||
포장분류 | II | ||
HS 번호 | 29269090 | ||
유해 물질 데이터 | 109-77-3(Hazardous Substances Data) | ||
독성 | LD50 i.p. in mice: 12.9 mg/kg (Jones, Israel) | ||
기존화학 물질 | KE-10262 | ||
유해화학물질 필터링 | 97-1-65 | ||
함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 말로노니트릴 및 이를 25% 이상 함유한 혼합물 |
말로노니트릴 C화학적 특성, 용도, 생산
개요
Malonitrile, also known as Malononitrile, is an aliphatic nitrile that can release cyanide through chemical or biological transformation. It was also used decades ago for treating certain forms of mental illness.화학적 성질
Malononitrile is a white powder or colorless, odorless crystalline substance. It may polymerize violently on prolonged heating at 130°C or at lower temperatures on contact with strong bases.용도
Malononitrile is an important building block for the syntheses of pharmaceuticals (e.g. triamterene, adenine and methotrexate), thiamin (vitamin B1), pesticides dyestuffs for color photography and synthetic fibers (e.g. vinylidene cyanide). Product Data Sheet정의
ChEBI: Malononitrile is a dinitrile that is methane substituted by two cyano groups. It is a dinitrile and an aliphatic nitrile.생산 방법
Malononitrile can be synthesized by a continuous method where preheated acetonitrile and cyanogen chloride are introduced into a tube reactor until the reaction mixture reaches a temperature of about 780°C. Another way to prepare malononitrile is by reacting phosphorus pentachloride with cyanoacetamide, or by using phosphorus pentoxide to react with malonamide or cyanoacetamide.DOI: 10.15227/orgsyn.010.0066
일반 설명
A white-colored crystalline solid. Denser than water and soluble in water. Toxic by ingestion and may severely irritate skin and eyes. May polymerize violently if exposed to temperatures above 266°F. Used to make other chemicals.공기와 물의 반응
Soluble in water.반응 프로필
Malononitrile is a white, low-melting powder (m. p. 30.5° C), toxic, combustible. Violent polymerization on contact with strong bases (sodium hydroxide, potassium hydroxide) or when heated above 130° C. When stored at 70-80° C for 2 months, spontaneous explosion (decomposition) occurred [Bretherick, 5th ed., 1995, p. 394].위험도
Toxic by ingestion and inhalation.화재위험
When heated to decomposition, Malononitrile emits highly toxic fumes (cyanide). May polymerize violently on prolonged heating. Avoid heat. Hazardous polymerization may occur, at prolonged heating at 266F or contact with strong bases at lower temperatures.공업 용도
Malononitrile is used primarily as an intermediate in the synthesis of drugs and vitamins (thiamine). It has also been employed in the manufacture of photosensitizes, acrylic fibers and dyestuffs and as an oil-soluble polar additive in lubricating oil.Malononitrile was used formerly in treatment of various forms of mental illness such as alteration of psychic functions and schizophrenic disorders.
Safety Profile
Poison by ingestion, skin contact, subcutaneous, intravenous, and intraperitoneal routes. A severe eye irritant. Combustible when exposed to heat or flame. Polymerizes violently when heated to 130°C or on contact with strong base. May spontaneously explode when stored at 70-80°C. To fight fire, use water, fog, spray, foam. When heated to decomposition it emits toxic fumes of NOx and CN-. See also NITRILES.환경귀착
When heated to decomposition, nitriles may release cyanide. Malonitrile appears to decompose rapidly in contact with soil and sediment.신진 대사
The in vitro metabolsim of malononitrile has been described by Stern et al. In the presence of thiosulphate, brain, liver and kidney slices metabolized malononitrile to thiocyanate. The formation of thiocyanate from malononitrile and thiosulphate was greatest in the presence of liver slices, lowest in brain, and intermediate with kidney slices. The liver enzyme system was saturated at a concentration of 3.3 mM malononitrile and a pH optimum of 7.0. This enzyme system was inhibited by cysteine and glutathione and inactivated by boiling. Stern et al indicated that thiosulphate increased cyanide and thiocyanate formed from malononitrile in tissue slices.Purification Methods
Crystallise the nitrile from water, EtOH, *benzene or chloroform. Distil it in a vacuum from, and store over, P2O5. [Bernasconi et al. J Am Chem Soc 107 7692 1985, Gratenhuis J Am Chem Soc 109 8044 1987, Beilstein 2 IV 1892.]비 호환성
Incompatible with strong bases. May polymerize violently on prolonged heating @ 129C, or in contact with strong bases at lower temperatures. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.말로노니트릴 준비 용품 및 원자재
원자재
준비 용품
1,4,5,8-나프탈렌테트라카르복실산
2-Aminonicotinic acid
2-Amino-3-cyanopyridine
2-AMINO-6-CHLORO-3,5-DICYANOPYRIDINE
4-AMINO-1,2,5-OXADIAZOLE-3-CARBONITRILE
2-Chloro-4,6-dimethoxypyrimidine
5-AMINO-4-CYANO-3-METHYL-THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER
2-AMINO-3-CYANO-4-METHYL-5-CARBMETHOXY THIOPHENE
2,4-DIAMINOPYRIMIDINE-5-CARBOXYLIC ACID
2-AMINO-3,5-DICYANOPYRIDINE
3-CYANO-7-ETHOXYCOUMARIN
2-AMINO-6-METHYL-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE
2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBONITRILE
2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE
2-AMINO-3-CYANO-4-CHLORO-5-FORMYLTHIOPHENE
2-AMINO-4-METHYL-QUINOLINE-3-CARBONITRILE
2,4,6-TRIAMINO-5-NITROPYRIMIDINE
2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBONITRILE
2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE
2,4,6-트리아미노피리미딘
3,5-Difluorophenylacetic acid
5-(AMINOMETHYL)PYRIMIDIN-4-AMINE
[2-[4-(dihexylamino)-2-methylbenzylidene]benzo[b]thien-3(2H)-ylidene]malononitrile S,S-dioxide
4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE
2-OXO-6-PHENYL-4-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
Levosimendan
4,6-DIAMINO-2-MERCAPTOPYRIMIDINE
3-CYANO-7-METHOXYCOUMARIN
5-AMINO-4-ISOXAZOLECARBONITRILE
2-AMINO-6-METHYL-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE-3-CARBONITRILE
4,6-DIAMINO-2-METHYLMERCAPTOPYRIMIDINE
2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXAMIDE
4-AMINOPYRIMIDINE-5-CARBONITRILE
4,6-Dimethyl-2-hydroxypyridine
5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE
4-Amino-6-methylpyrimidine-5-carbonitrile ,97%
4-AMINOPYRIMIDINE-5-CARBOXAMIDE
아짐설푸론
5-AMINO-1-PHENYLPYRAZOLE-4-CARBONITRILE
Solvent Red 197
말로노니트릴 공급 업체
글로벌( 468)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Baynoe Chem (Suzhou) Co., Ltd. | +86-512 65869404 +86-18934593683 |
sales06@baynoe.com | China | 292 | 58 |
Suzhou Yuanrui Bio-Tech Co., Ltd | +86-18106132862 +86-18106132862 |
sales02@yuanruibio.com | China | 278 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2989 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |