Nepicastat hydrochloride
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Nepicastat hydrochloride 속성
- 저장 조건
- Inert atmosphere,Store in freezer, under -20°C
- 용해도
- DMSO: 용해성10mg/mL, 투명
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
- InChIKey
- DIPDUAJWNBEVOY-PPHPATTJSA-N
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
Nepicastat hydrochloride C화학적 특성, 용도, 생산
개요
Nepicastat is an inhibitor of dopamine β-hydroxylase (DBH; IC50 = 9 nM for the purified human enzyme). It is selective for DBH over a panel of 12 enzymes and 13 neurotransmitter receptors (IC50s or Kis = >10 μM). Nepicastat dose-dependently reduces norepinephrine content and increases dopamine content in the mesenteric artery, left ventricle, and cerebral cortex in spontaneously hypertensive rats, as well as in the renal artery, left ventricle, and cerebral cortex in beagle dogs. It attenuates increases in diastolic blood pressure and heart rate induced by preganglionic sympathetic nerve stimulation in pithed spontaneously hypertensive rats when administered orally at doses of 10 and 30 mg/kg. Nepicatstat (50 mg/kg) reduces the progressive ratio response for cocaine, but not food or sucrose pellets, in rats. It also reduces reinstatement of cocaine-seeking behavior induced by cues, yohimbine , or foot-shock in rats.용도
Nepicastat Hydrochloride is a potent and selective dopamine β-hydrolase inhibitor. Used in cardiovascular treatment where deficiencies in ventricles results in heart failure.Nepicastat hydrochloride 준비 용품 및 원자재
원자재
준비 용품
Nepicastat hydrochloride 공급 업체
글로벌( 104)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| Wuhan Monad Medicine Tech Co.,LTD | 02768782018 18771942761 |
sales01@whmonad.com | CHINA | 992 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
| Apeloa Pharmaceutical Co., Ltd. | +86-0571-87635730 +8615858229168 |
chem1022@hengdian-group.com | China | 1469 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29474 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 |
shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10523 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 |
contact@labnetwork.com | China | 19994 | 58 |
| Alfa Chemistry | +1-5166625404 |
Info@alfa-chemistry.com | United States | 21317 | 58 |