A 967079

A 967079 구조식 이미지
카스 번호:
1170613-55-4
상품명:
A 967079
동의어(영문):
A 967079;(1E,3E)-1-(4-Fluorophenyl)-2-Methyl-1-penten-3-one oxiMe;(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime;1-Penten-3-one, 1-(4-fluorophenyl)-2-methyl-, oxime, (1E,3E)-;TRP Channel,inhibit,Transient receptor potential channels,A 967079,Inhibitor,A-967079,A967079
CBNumber:
CB22650391
분자식:
C12H14FNO
포뮬러 무게:
207.24
MOL 파일:
1170613-55-4.mol
MSDS 파일:
SDS

A 967079 속성

끓는 점
324.4±34.0 °C(Predicted)
밀도
1.03±0.1 g/cm3 (20 ºC 760 Torr)
저장 조건
2-8°C
용해도
DMSO: ≥12mg/mL
산도 계수 (pKa)
12.23±0.40(Predicted)
물리적 상태
가루
색상
흰색에서 황갈색까지
안정성
-20°C에서 DMSO에 최대 2개월 동안 보관 가능

안전

WGK 독일 3
HS 번호 2928009090

A 967079 C화학적 특성, 용도, 생산

용도

(1E,3E)- 1-(4-Fluorophenyl)-2-methyl-1-penten-3-one Oxime is a transient receptor potential ankyrin 1 (TRPA1) antagonist and has been investigated as potential analgesic drug for the treatment of chronic pain.

일반 설명

A-967079 prevents neuropathic and inflammatory pain. It reduces cold allodynia, which is produced by nerve injury.

Biochem/physiol Actions

A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC50′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation.

A 967079 준비 용품 및 원자재

원자재

준비 용품


A 967079 공급 업체

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