Teriparatide acetate
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Teriparatide acetate 속성
- 녹는점
- >205oC (dec.)
- RTECS 번호
- SQ7770000
- 저장 조건
- −20°C
- 용해도
- DMSO(약간 용해됨), 물(약간 용해됨)
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- 수용성
- Soluble to 0.40 mg/ml in water
- 시퀀스
- H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH
- 안정성
- 흡습성
- CAS 데이터베이스
- 52232-67-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
WGK 독일 | 3 | ||
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HS 번호 | 2937190000 | ||
유해 물질 데이터 | 52232-67-4(Hazardous Substances Data) |
그림문자(GHS): | ||||||||||||||||||||||
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신호 어: | Warning | |||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Teriparatide acetate C화학적 특성, 용도, 생산
용도
A fragment of human parathyroid hormone (hPTH) peptide sequence containing the 34 N-terminal residues of hPTH. This fragment was also found to be an agonist at PTH1 and PTH2 receptors.일반 설명
Teriparatide is a recombinantform of parathyroid hormone, which is used for the treatmentof osteoporosis in men and postmenopausal women.The N-terminal region possesses 34 amino acids, which areidentical to the biologically active region of the 84-aminoacid sequence of human parathyroid hormone. It has beenshown to act on osteoblasts to stimulate new bone growthand improve bone density.Pharmacokinetics
If administered once daily or intermittently, teriparatide preferentially enhances osteoblastic function,and bone formation occurs. Continuous exposure to endogenous PTH may result in poor skeletal composition because of enhanced osteoclast-mediated bone resorption. After 18 months of treatment, lumbar BMD increased up to 12% in postmenopausal women. After 10 months of treatment, 53% of men had an increase of 5% or greater in spine BMD. The risk for developing new vertebral fractures was reduced by 65% after 21 months of treatment, and the number of nonvertebral fragility fractures was reduced by 53%.Clinical Use
In 2002, the U.S. FDA approved teriparatide for the treatment of postmenopausal osteoporosis in patients who have a high risk of fracture as well as to increase bone mass in men with primary or hypogonadal osteoporosis who have a high risk of fracture. Teriparatide is recombinant human PTH 1-34, the biologically active portion of the endogenously produced preprohormone. Unlike the bisphosphonates, which are classified as bone restorative agents, teriparatide is the first approved bone-forming agent. Bone formation is possible because of the ability of this agent to increase the number of osteoblasts. Although teriparatide enhances the function of both osteoclasts and osteoblasts, the exposure incidence dictates its effect on the skeleton.부작용
Temporary increases in serum calcium levels occur following administration of teriparatide. As a result, this agent is contraindicated in patients who are predisposed to hypercalcemia. Some evidence suggests that these elevations in serum calcium levels may cause a patient who is taking digitalis to experience digitalis toxicity (39). Teriparatide should not be prescribed to patients with Paget's disease, children, young adults, women who are pregnant or nursing, and those patients who have received skeletal radiation therapy. Because of an increased incidence of osteosarcoma (malignant bone tumors) observed in rats, teriparatide also carries a black box warningDosage
Teriparatide acetate requires subcutaneous injection into the thigh or abdominal wall, and the recommended dose is 20 mcg once daily. If symptoms of orthostatic hypotension occur, it is administered while the patient is sitting or lying down. It is not recommended to use the drug for more than 2 years in the lifetime of the patient. Use teriparatide injection with caution in patients receiving digoxin. Transient hypercalcemia may predispose patients to digitalis toxicity.Teriparatide acetate 준비 용품 및 원자재
원자재
준비 용품
Teriparatide acetate 공급 업체
글로벌( 393)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Zhejiang Hangyu API Co., Ltd | +8617531972939 |
anna@api-made.com | China | 2944 | 58 |
Cellmano Biotech Limited | 0551-65326643 18156095617 |
info@cellmano.com | China | 999 | 58 |
qingdao future trading Co., Ltd | +86-13335044410 +86-13335044410 |
cui56813@163.com | China | 110 | 58 |
Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 |
xinshengkeji@xsmaterial.com | China | 1100 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 11013 | 58 |
Hebei Anlijie Biotechnology Co., Ltd | +8619031013551 |
ably@aljbio.com | China | 177 | 58 |
Hebei Weimiao Import and Export Trade Co., Ltd. | +undefined19948166995 |
sale01@hbweimiao.com | China | 64 | 58 |
Shanghai Getian Industrial Co., LTD | +undefined15373193816 |
mike@ge-tian.com | China | 272 | 58 |
Shanghai Chinqesen Biotechnology Co., Ltd. | +86-16628886292 +86-19521323435 |
sales2@qschem-pharma.com | China | 46 | 58 |
Shanghai Yunao International Trade Co., Ltd | +8617621705551 |
asdf@shanghaihg.cn | China | 265 | 58 |
Teriparatide acetate 관련 검색:
디스프로슘 트리(2,2,6,6-테트라메틸-3,5-헵탄디오네이트) 알루미늄 아세틸아세토네이트 아세틸아세톤산 구리 아세틸아세토산 제2철 코발트(II) 아세틸아세토네이트 하이드레이트 실버 아세틸아세토네이트
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