DM4
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DM4 속성
- 녹는점
- 185-187 °C (decomp)
- 끓는 점
- 943.2±65.0 °C(Predicted)
- 밀도
- 1.29±0.1 g/cm3(Predicted)
- 저장 조건
- Store at -20°C
- 용해도
- DMSO : 100 mg/mL (128.14 mM)
- 산도 계수 (pKa)
- 9.82±0.70(Predicted)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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신호 어: | Danger | |||||||||||||||||||||||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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DM4 C화학적 특성, 용도, 생산
개요
Ravtansine (DM4) is a maytansinoid, a chemical derivative of maytansine being investigated as the cytotoxic payload of a number of antibody-drug conjugates (ADCs).M4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate.용도
N2''-Deacetyl-N2''-(4-mercapto-4-methyl-1-oxopentyl)-maytansine is an intermediate used to prepare semisynthetic maytansine analogs which can be conjugated with antibodies for the targeted treatment of cancer.생물학적 활성
The anticancer properties of maytansinoids have been attributed to their ability to disrupt microtubule function. The maytansinoid emtansine (DM1), for example, binds at the ends of microtubules and thereby suppress their dynamic instability. Other maytansinoids include: Ansamitocin; Mertansine/emtansine (DM1); Ravtansine/soravtansine (DM4).참고 문헌
[1] Giulio Lovato . “HPLC-DAD validated method for DM4 and its metabolite S-Me-DM4 quantification in biological matrix for clinical and pharmaceutical applications.” Journal of pharmaceutical and biomedical analysis 235 (2023): Article 115642.DM4 준비 용품 및 원자재
원자재
Pentanenitrile, 4-mercapto-4-methyl-
L-Alanine, N-methyl-N-[4-methyl-4-(methyldithio)-1-oxopentyl]-
Pentanoic acid, 4-methyl-4-(methyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester
DM4-Sme
Maytansinol
준비 용품
DM4 공급 업체
글로벌( 123)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shanghai Minbiotech Co., Ltd. | +8617315815539 |
sales@minbiotech.com | CHINA | 129 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 |
contact@fuxinpharm.com | China | 10297 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 |
contact@trustwe.com | China | 5738 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10326 | 58 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; |
laboratory@coreychem.com | China | 30255 | 58 |
Zhejiang Huida Biotech Co., LTD | 008613515763466 8615669048680 |
wendy@huidabiotech.com | CHINA | 87 | 58 |