페니토인 나트륨 C화학적 특성, 용도, 생산
화학적 성질
White or almost white, crystalline powder, slightly hygroscopic.
용도
antibacterial
일반 설명
Phenytoin sodium, 5,5-diphenyl-2,4-imidazolidinedione, 5,5-diphenylhydantoin,diphenyl-hydantoin sodium (Dilantin), has been used fordecades in the control of grand mal types of epilepticseizure. It is structurally analogous to the barbiturates butdoes not possess their extensive sedative properties. Thecompound is available as the sodium salt. Solutions for parenteraladministration contain 40% propylene glycol and10% alcohol to dissolve the sodium salt.
Clinical Use
Phenytoin sodium’s cardiovascular effects were uncoveredduring observation of toxic manifestations of the drugin patients being treated for seizure disorders. Phenytoinsodium was found to cause bradycardia, prolong the PRinterval, and produce T-wave abnormalities on electrocardiograms.It is a class IB antiarrhythmic agent. Today,phenytoin sodium’s greatest clinical use as an antiarrhythmicdrug is in the treatment of digitalis-induced arrhythmias.34 Its action is similar to that of lidocaine. It depressesventricular automaticity produced by digitalis, without adverseintraventricular conduction. Because it also reversesthe prolongation of AV conduction by digitalis, phenytoinsodium is useful in supraventricular tachycardias caused bydigitalis intoxication.
Safety Profile
Confirmed
carcinogen. Experimental teratogen. Other
experimental reproductive effects. Poison by
ingestion, subcutaneous, intravenous, and
intraperitoneal routes. Human systemic
effects by ingestion: anorexia, respiratory
depression, nausea or vomiting,
hemorrhage, dermatitis, and endocrine
effects. Mutation data reported. An
anticonvulsant and cardiac depressant used
for the treatment of grand mal and
psychomotor seizures. When heated to
decomposition it emits very toxic fumes of
NOx and Na2O.
Carcinogenicity
Phenytoin and its sodium salt are reasonably anticipated to be human carcinogens based on sufficient evidence from studies in experimental animals.
Solubility in water
1 g dissolves in ca. 66 ml of water. The aqueous solution is turbid unless the pH is adjusted above 11.7, which is the pH of the saturated solution. 1 g dissolves in 10.5 mL of alcohol. Practically insoluble in ether and chloroform.
페니토인 나트륨 준비 용품 및 원자재
원자재
준비 용품
