ChemicalBook
Chinese English Japanese Germany Korea

LEVOCABASTINE

LEVOCABASTINE 구조식 이미지
카스 번호:
79516-68-0
상품명:
LEVOCABASTINE
동의어(영문):
Levocabastin;LEVOCABASTINE;Levocabastina;Levocabastinum;Unii-H68bp06S81;Levocabastinum [latin];Levocabastina [spanish];Levocabastine [inn:ban];LEVOCABASTINE USP/EP/BP;79547-78-7 (Hydrochloride)
CBNumber:
CB2307787
분자식:
C26H29FN2O2
포뮬러 무게:
420.52
MOL 파일:
79516-68-0.mol

LEVOCABASTINE 속성

끓는 점
589.9±50.0 °C(Predicted)
밀도
1.23
산도 계수 (pKa)
3.57±0.40(Predicted)

안전

LEVOCABASTINE C화학적 특성, 용도, 생산

Originator

Livostin,Janssen-Cilag,Belgium

용도

Anti histaminic.

Manufacturing Process

4-Cyano-4-(4-fluorophenyl)-heptanedioic acid diethyl ester is obtained by addition of ethyl acrylate to the anion from p-fluorophenylacetonitrile. By base catalyzed cyclization of these diester (sodium methoxide, 60°C, xylene) is synthesized an intermediate that after decarboethoxylation gives 1-(4- fluorophenyl)-4-oxycyclohexanecarbonitrile. By condensation of 3-methyl-5- phenylpiperidine-4-carboxylic acid benzyl ester and 1-(4-fluorophenyl)-4- oxycyclohexanecarbonitrile under reductive hydrogenation conditions (palladium-on-charcoal catalyst, 50°C, in ethanol) is prepared benzyl ester 4- piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl- 4-phenyl-, (3S-(1(cis),3α,4β))-. The benzyl protecting group is then removed by hydrogenation method and 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4- fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, (3S-(1(cis),3α,4β))- obtained is transformed into 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl) cyclohexyl)-3-methyl-4-phenyl-, hydrochloride, (3S-(1(cis), 3α,4β))- (Levocabastine hydrochloride)

상표명

Livostin (Novartis).

Therapeutic Function

Antihistaminic

LEVOCABASTINE 준비 용품 및 원자재

원자재

준비 용품


LEVOCABASTINE 공급 업체

글로벌( 20)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47496 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58
Shaanxi Dideu Medichem Co. Ltd
18192503167 +86-29-89586680
+86-29-88380327 1005@dideu.com CHINA 9937 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 29986 58
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1938 70
BOC Sciences 16314854226
sales@bocsci.com United States 9932 65
Jiangsu yize medical technology co. LTD 18550739526
QQ: 3394205705 23903480@qq.com China 9987 58

Copyright 2019 © ChemicalBook. All rights reserved