PAXILLINE
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PAXILLINE 속성
- 인화점
- 2℃
- 저장 조건
- 2-8°C
- 용해도
- DMSO, 아세톤 또는 클로로포름에 용해됩니다.
- 물리적 상태
- 가루
- 색상
- 희미한 노란색
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T,Xn,F | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 23/24/25-36/37/38-41-36-20/21/22-11 | ||
| 안전지침서 | 26-36/37/39-45-36/37-16 | ||
| 유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | DJ2830000 | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| HS 번호 | 29419090 |
PAXILLINE C화학적 특성, 용도, 생산
개요
A complex alkaloid, paxilline occurs in the mycelium of the mold Penicillium paxilli. The structure has been confirmed by X-ray crystallography. The crystals are orthorhombic with space group P2 12 121 and a = 31.009, b = 11.522 and c = 7.70 A.화학적 성질
Powder용도
Paxilline is a tremorgenic mycotoxin isolated from species of Penicillium, Acremonium and Emericella. Paxilline selectively blocks high-conductance Ca2+-activated potassium channels and inhibits binding to the cerebellar inositol 1,4,5-triphosphate (InsP(3)) receptor.생물학적 활성
Potent blocker of high-conductance Ca 2+ -activated K + (BK Ca ) channels. Binds to the α -subunit of BK Ca (K i = 1.9 nM for block of currents in α -subunit-expressing oocytes) and enhances binding of charybdotoxin to BK Ca channels in vascular smooth muscle. Also inhibits sarco/endoplasmic reticulum Ca 2+ -ATPase (IC 50 = 5-50 μ M).효소 저해제
This BKCa/KCa1.1) channel blocker (FW = 435.56 g/mol; CAS 57186-25-1; Solubility: 100 mM in DMSO), also named (2R,4bS,6aS,12bS,12cR,14aS)- 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1- methylethyl)-12b,12c-dimethyl-2H-pyrano[2'',3'': 5',6']benz[1',2':6,7]indeno [1,2-b]indol-3(4bH)-one, binds to the α-subunit of BKCa, exhibiting a Ki value of 1.9 nM in blocking currents in α-subunit-expressing oocytes and enhancing binding of to BKCa channels in vascular smooth muscle. (See Charybdotoxin) Paxilline also inhibits sarco/endoplasmic reticulum Ca2+-ATPase, IC50 = 5 - 50 μM.참고 문헌
Springer et ai., Tetrahedron Lett., 2531 (1975)PAXILLINE 준비 용품 및 원자재
원자재
준비 용품
PAXILLINE 공급 업체
글로벌( 110)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 |
13119157289@163.com | China | 2971 | 58 |
| Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15848 | 69 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 |
sales@meilune.com | China | 4647 | 58 |
| TargetMol Chemicals Inc. | 021-33632979 15002134094 |
marketing@targetmol.com | China | 7934 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 |
info@emmx.com | United States | 8449 | 60 |
PAXILLINE 관련 검색:
암피실린 무수산염 디아세톤알코올 4-터트-뷰틸사이클로헥사놀
TRANS-4-TERT-BUTYLCYCLOHEXANOL
4-Methyl-3-decen-5-ol
2-TERT-BUTYL-1H-INDOLE
4-TERT-AMYLCYCLOHEXANOL
TRANS-4-TERT-PENTYLCYCLOHEXANOL
1-VINYLCYCLOHEXANOL 97
4-METHYL-4-HEPTEN-3-OL
3,3-DIMETHYLCYCLOHEXYLIDENEACETALDEHYDE
PAXILLINE
1 2 3 4-TETRAHYDROCYCLOPENT(B) INDOLE
5,6-dihydro-2H-pyran-3-methanol
3-N-OCTYLPYRROLE
2,7-dimethyloct-5-en-4-one
2-CYCLOHEXYL-1H-INDOLE
3-HEPTYLPYRROLE