Galantamine Hydrobromide
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Galantamine Hydrobromide 속성
- 녹는점
- 256 °C
- 알파
- D20 -93.1° (c = 0.1015 in 15 ml H2O)
- 굴절률
- -95 ° (C=1.4, H2O)
- 저장 조건
- Inert atmosphere,Store in freezer, under -20°C
- 용해도
- 물에 거의 용해되지 않으며 무수 에탄올에는 매우 약간 용해됩니다. 알칼리 수산화물의 묽은 용액에 용해됩니다.
- 물리적 상태
- 백색 내지 황백색의 결정성 고체.
- 색상
- White to Orange to Green
- 수용성
- 물 또는 DMSO에 용해됨
- Merck
- 14,4340
- 주요 응용
- pharmaceutical (small molecule)
- InChI
- InChI=1/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/s3
- InChIKey
- QORVDGQLPPAFRS-ORFATOSYNA-N
- SMILES
- [C@@]123CCN(C)CC4=CC=C(OC)C(O[C@H]1C[C@@H](O)C=C2)=C34.Br |&1:0,14,16,r|
- LogP
- 1.750 (est)
- CAS 데이터베이스
- 1953-04-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 25 | ||
| 안전지침서 | 45-36/37/39-22 | ||
| 유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | DF8075000 | ||
| 위험 등급 | 6.1 | ||
| 포장분류 | II | ||
| HS 번호 | 29399990 | ||
| 스토리지 클래스 | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Acute Tox. 3 Oral | ||
| 독성 | LD50 i.v. in mice (mg/kg): 5.2 ± 0.2 (Friess) |
Galantamine Hydrobromide C화학적 특성, 용도, 생산
화학적 성질
Galantamine hydrobromide is a white to almost white powder and is sparingly soluble in water.용도
Galantamine hydrobromide (marketed as Reminyl) is one of a group of three drugs for people with Alzheimer's disease called cholinesterase inhibitors. The other two are called donepezil hydrochloride (common brand name Aricept) and rivastigmine (common brand name Exelon). It is a selective acetylcholinesterase inhibitor that for the treatment and prevention of Alzheimer's disease and other diseases resulting from reduced neuronal metabolism.일반 설명
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.Galantamine Hydrobromide, a reversible, competitive acetyl cholinesterase inhibitor, is suggested for the remedy of mild to moderate dementia of the Alzheimer′s type.
생물학적 활성
Long-acting, centrally active acetylcholinesterase inhibitor (IC 50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β -amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.Galantamine Hydrobromide 준비 용품 및 원자재
원자재
준비 용품
Galantamine Hydrobromide 공급 업체
글로벌( 464)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Chongqing jooe co., ltd | +undefined86-15223382610 |
info@jooe.com | China | 15976 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 |
Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 |
sales1@chuanghaibio.com | China | 5237 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 |
deasea125996@gmail.com | China | 2472 | 58 |
| Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 |
info@hyper-chem.com | China | 310 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 |
sarah@tnjone.com | China | 1143 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 |
info@binbobiological.com | China | 477 | 58 |
| Shaanxi Xianhe Biotech Co., Ltd | +86-17709210191; +8617709210191 |
Jerry@xhobio.com | China | 906 | 58 |
| Xi an Biohorlden Industry Trade Co Ltd | +86-18829283179 +86-13636819721 |
sales@horlden.com | China | 334 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 |
jiuyitime@fdachem.com | China | 16513 | 58 |