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Tolclofos-methyl

Tolclofos-methyl 구조식 이미지
카스 번호:
57018-04-9
상품명:
Tolclofos-methyl
동의어(영문):
S-3349;RIZOLEX;Basilex;Risolex;Risolex(TM);Tolcofos-methyl;olclofos-methyl;TOLCLOFOS-METHYL;TOLCHLOFOS-METHYL;Tolchlophos-methyl
CBNumber:
CB2451996
분자식:
C9H11Cl2O3PS
포뮬러 무게:
301.13
MOL 파일:
57018-04-9.mol

Tolclofos-methyl 속성

녹는점
78-80°C
끓는 점
338.5±52.0 °C(Predicted)
밀도
1.401±0.06 g/cm3(Predicted)
증기압
1.84 x 10-3 (Pa 25 °C)
인화점
>100 °C
저장 조건
2-8°C
물리적 상태
neat
수용성
1.10 mg l-1 (25 °C)
Merck
13,9587
BRN
2136521
InChIKey
OBZIQQJJIKNWNO-UHFFFAOYSA-N
CAS 데이터베이스
57018-04-9(CAS DataBase Reference)
NIST
Phosphorothioic acid, o-(2,6-dichloro-4-methylphenyl) o,o-dimethyl ester(57018-04-9)
EPA
Tolclofos-methyl (57018-04-9)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi,N
위험 카페고리 넘버 43-50/53
안전지침서 22-24/25-61-60-37-24
유엔번호(UN No.) UN 3077 9 / PGIII
WGK 독일 3
RTECS 번호 TF0460000
HS 번호 29201900
유해 물질 데이터 57018-04-9(Hazardous Substances Data)
독성 LD50 in male, female rats, male, female mice (mg/kg): ~5000, ~5000, 3500, 3600 orally; all >5000 dermally; ~5000, 4900, 1070, 1260 i.p.; all >5000 s.c. (Ohtsuki, Fujinami)
기존화학 물질 KE-10214
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H410 장기적 영향에 의해 수생생물에 매우 유독함 수생 환경유해성 물질 - 만성 구분 1 경고 P273, P391, P501
예방조치문구:
P273 환경으로 배출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

Tolclofos-methyl MSDS


2,6-Dichloro-4-methylphenyl O,O-dimethyl phosphorothioate

Tolclofos-methyl C화학적 특성, 용도, 생산

용도

Agricultural fungicide.

용도

Tolclofos-methyl is a non-systemic organophosphorus fungicide with both protective and curative activities that control soil-borne diseases caused by Rhizoctonia solani, Corticium rolfsii, Tphula incamata and Typhula ishikariensis in/on potatoes, sugar beet, cotton and peanuts.

정의

ChEBI: An organic thiophosphate that is 2,6-dichloro-4-methylphenol in which the hydrogen of the hydroxy group group has been replaced by a dimethoxyphosphorothioyl group. Tolclofos-methyl is a phospholipid biosynthesis inhibitor and fungicide that is used for co trolling soil-borne diseases caused by Typhula incarnata, Corticium rolfsii, Typhula ishikariensis, and Rhizoctonia solani.

신진 대사 경로

Tolclofos-methyl underwent common degradation and metabolic pathways in water, soil, plants and animals. These reactions are well documented for most organophosphorus compounds and include oxidative desulfuration, hydroxylation/oxidation of the 4-methyl group to the alcohol and carboxylic acid, cleavage of the P-O-aryl linkage, O-demethylation and conjugation. In addition to the above reactions, photolytic isomerisation to the thionate (P=S) was also observed. A schematic presentation of the primary metabolic pathways for tolclofosmethyl is illustrated in Scheme 1.

Degradation

[14C-phenyl]Tolclofos-methyl(1) was stable to hydrolytic degradation at pH 5, 7 and 9 at 22°C with DT50 values of 139, 417 and 238 days, respectively. Higher temperature led to a more rapid hydrolysis and two hydrolysis products were detected. O-Demethylation and oxidative desulfuration were the major reactions to yield 2,6-dichloro-p-tolyl methyl hydrogen phosphorothioate (2) and toclofos-methyl oxon (O-2,6-dichlorop- tolyl O,O-dimethyl phosphate, 3), respectively. Cleavage of the P-O-aryl linkage yielded 2,6-dichloro-4-methylphenol(4) as a minor degradation product (WHO, 1994).
Tolclofos-methyl degraded in water under natural sunlight irradiation with DT50 values of 44 days (in distilled water), 15-28 days (in natural river and pond water) and less than 2 days in 2% acetone/water. The major degradation reactions included oxidative desulfuration to yield compound 3 and O-demethylation to yield compound 2. The major photodegradation products in river and pond waters and soil thinlayer surfaces were compounds 2, 3, 4 and the O-demethylated 3 (2,6- dichloro-p-tolyl methyl hydrogen phosphate, 5) (Mikami et al., 1984). In acetone solution, demethylation of the isomerisation product [2,6- dichloro-p-tolyl O,S-dimethyl phosphorothioate (6)] yielded 2,6-dichlorop- tolyl S-methyl hydrogen phosphorothioate (7) and 2,6-dichloro-p-tolyl dihydrogen phosphate (8) as the major photodegradates (Mikami et al., 1984).

Toxicity evaluation

Its acute oral toxicity is very low in comparison with a thio-ester type of other organophosphorus fungicides (edifenphos, iprobenfos, and pyrazophos).

Tolclofos-methyl 준비 용품 및 원자재

원자재

준비 용품


Tolclofos-methyl 공급 업체

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