Geldanamycin-Biotin
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Geldanamycin-Biotin 속성
- 끓는 점
- 1275.6±65.0 °C(Predicted)
- 밀도
- 1.28±0.1 g/cm3(Predicted)
- 저장 조건
- -20°C
- 용해도
- DMSO에 용해됨(최대 10mg/ml)
- 산도 계수 (pKa)
- 8.60±0.70(Predicted)
- 물리적 상태
- 가루
- 색상
- 보라
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
안전
| WGK 독일 | 3 |
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Geldanamycin-Biotin C화학적 특성, 용도, 생산
용도
Geldanamycin-biotin is a biotinylated ligand for affinity purification of HSP-90 and HSP-90-dependent proteins.Biochem/physiol Actions
Geldanamycin-Biotin is a benzoquinone ansamycin antitumor antibiotic. Geldanamycin binds specifically to Hsp90 (HeatShock Protein 90). and to its endoplasmic reticulum homologue GP96. The Hsp90 chaperone is required for the activation of several families of eukaryotic protein kinases and nuclear hormone receptors, many of which are proto-oncogenic and play a prominent role in cancer. The geldanamycin antibiotic has antiproliferative and antitumor effects, as it binds to Hsp90, inhibits the HSP90-mediated conformational maturation/refolding reaction, and results in the degradation of Hsp90 substrates. Hsp90 also plays a key role in regulating the physiology of cells exposed to environmental stress and thus, geldanamycin interferes with cellular stess response.Geldanamycin-Biotin 준비 용품 및 원자재
원자재
준비 용품
Geldanamycin-Biotin 공급 업체
글로벌( 2)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |