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Proglumide

Proglumide 구조식 이미지

카스 번호:: 6620-60-6

상품명:: Proglumide

동의어(영문):: ProM;kxm;xyde;242dl;cr242;milid;nulsa;w5219;milide;Promid

CBNumber:: CB2479493

분자식:: C18H26N2O4

포뮬러 무게:: 334.41

MOL 파일:: 6620-60-6.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 177

Proglumide 속성

녹는점: 148-150°C

끓는 점: 471.21°C (rough estimate)

밀도: 1.1944 (rough estimate)

굴절률: 1.5700 (estimate)

저장 조건: Keep in dark place,Sealed in dry,Room Temperature

용해도: DMSO(약간 용해됨), 메탄올(약간 용해됨)

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 4.51±0.10(Predicted)

색상: 크리스탈

CAS 데이터베이스: 6620-60-6(CAS DataBase Reference)

EPA: Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo- (6620-60-6)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

독성	LD50 in mice (mg/kg): 2211-2649 i.v.; 7350-8861 orally (Rovati)

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고	P264, P270, P301+P312, P330, P501
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

Proglumide C화학적 특성, 용도, 생산

개요

Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application.
Proglumide is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide selective blocks CCK’s effects in the central nervous system (CNS). Proglumide has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide also has antiepileptic and antioxidant activities.

화학적 성질

White Solid

용도

Anticholinergic.

부작용

An interesting side effect of proglumide is that it enhances the analgesia produced by opioid drugs, and can prevent or even reverse the development of tolerance to opioid drugs. This can make it a useful adjuvant treatment to use alongside opioid drugs in the treatment of chronic pain conditions such as cancer, where opioid analgesics may be required for long periods and development of tolerance reduces clinical efficacy of these drugs.
Proglumide has also been shown to act as a δ-opioid agonist, which may contribute to its analgesic effects.

Safety Profile

Moderately toxic by severalroutes. An experimental teratogen. When heated todecomposition it emits toxic fumes of NOx.

효소 저해제

This anticholinergic agent (FWfree-acid = 334.42 g/mol; CAS 6620-60-6), also known as DL-4-benzamido-N,N-dipropylglutaramic acid and 4- (benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid, is a cholecystokinin receptor antagonist. Proglumide A also exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It finds use clinically as a therapy for gastrointestinal ulcers. Target(s): cholecystokinin receptor; gastrin receptor.

Proglumide 준비 용품 및 원자재

원자재

디프로필아민 염화벤조일

준비 용품

Proglumide 공급 업체

글로벌( 177)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hebei Lingding Biotechnology Co., Ltd.	+86-18031140164 +86-19933155420	erin@hbldbiotech.com	China	878	58
Henan Tengmao Chemical Technology Co. LTD	+8615238638457	salesvip2@hntmhg.com	China	415	58
Liaoning Pharmaceutical Innovation Co., Ltd	+8616588669988	sales@pipharma.com.cn	China	148	58
Sigma Audley	+86-18336680971 +86-18126314766	nova@sh-teruiop.com	China	525	58
Shanghai Aosiris new Material Technology Co., LTD	86-15139564871 +8615139564871	wrjmoon2000@163.com	China	352	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2989	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58

Proglumide 관련 검색:

시메티딘 Carbenoxolone Atropine Cisapride PROGLUMETACIN MALEATE Proglumide DEXLOXIGLUMIDE LOXIGLUMIDE LORGLUMIDE AMIGLUMIDE PROGLUMIDE SODIUM SALT SELECTIVE CHOLECY STOK,PROGLUMIDE SODIUM,PROGLUMIDE, SODIUM SALT Tomoglumide Proglumide CP2000 L-Proglumide D-Proglumide (+-)-4-((3,4-Dimethylbenzoyl)amino)-5-((3-methoxypropyl)pentylamino)-5 -oxopentanoic acid (+-)-4-((3,4-Difluorobenzoyl)amino)-5-((3-methoxypropyl)pentylamino)-5 -oxopentanoic acid 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-(2 -((4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl)oxy)ethoxy)-2-ox oethyl ester, (+-)-