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Deruxtecan

Deruxtecan 구조식 이미지

카스 번호:: 1599440-13-7

상품명:: Deruxtecan

동의어(영문):: Deruxtecan;MC-GGFG-Exetecan;Deruxtecan analog;Deruxtecan（DX-8951）;Ibandronate Impurity 32;MC-GGFG-Exetecan Deruxtecan analog;Drug-Linker Conjugates for ADC,Inhibitor,inhibit,Deruxtecan;Glycinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[[2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]-;N-[(S)-10-Benzyl-1-[[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-1,2,3,9,10,12,13,15-octahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-1-yl]amino]-1,6,9,12,15-pentaoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-yl]-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide;N-((S)-10-Benzyl-1-(((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)amino)-1,6,9,12,15-pentaoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-yl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide

CBNumber:: CB24796642

분자식:: C52H56FN9O13

포뮬러 무게:: 1034.05

MOL 파일:: 1599440-13-7.mol

속성

안전

용도

공급 업체 96

Deruxtecan 속성

끓는 점: 1491.1±65.0 °C(Predicted)

밀도: 1.48±0.1 g/cm3(Predicted)

용해도: DMSO:67.5(Max Conc. mg/mL);65.28(Max Conc. mM)

산도 계수 (pKa): 11.18±0.40(Predicted)

안전

Deruxtecan C화학적 특성, 용도, 생산

용도

Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

Mechanism of action

Deruxtecan is attached to the antibody by a peptide linker. After trastuzumab deruxtecan binds to HER2 found on malignant cells, it is internalized and linker cleavage occurs through the actions of lysosomal enzymes. After it is released through cleavage, DXd causes targeted DNA damage and apoptosis in cancer cells, due to the ability to cross cell membranes.

Deruxtecan 준비 용품 및 원자재

원자재

준비 용품

Deruxtecan 공급 업체

글로벌( 96)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Xilinglab Co., Ltd.	+8618381337976	bd@xilinglab.com	China	86	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	7019	58
Chengdu Pukang Biotechnology Co., Ltd	028-82550498	export@pu-kang.com	CHINA	210	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9635	58
Shenzhen Shengda Pharma Limited	755-85269922 +8613424394241	sales@shengdapharm.com	CHINA	310	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58

Deruxtecan 관련 검색:

Deruxtecan