STAUROSPORINE
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STAUROSPORINE 속성
- 녹는점
- 270°C
- 알파
- D25 +35.0° (c = 1 in methanol); D22 +56.1° (c = 0.14 in methanol)
- 끓는 점
- 677.5±55.0 °C(Predicted)
- 밀도
- 1.56±0.1 g/cm3(Predicted)
- RTECS 번호
- KD5084000
- 저장 조건
- 2-8°C
- 용해도
- DMSO: 용해될 수 있다
- 물리적 상태
- 흰색에서 연한 노란색 고체
- 산도 계수 (pKa)
- 14.25±0.70(Predicted)
- 색상
- 미색에서 옅은 노란색까지
- 수용성
- DMSO 또는 에탄올에 용해됩니다. 디메틸 설폭사이드, 디메틸 포름아미드, 에틸 아세테이트, 뜨거운 아세톤 및 에탄올에 용해됩니다. 클로로포름과 메탄올에 약간 용해됩니다. 물에 불용성.
- BRN
- 1060573
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO의 솔루션은 -20°에서 최대 4개월 동안 보관할 수 있습니다.
- InChIKey
- HKSZLNNOFSGOKW-WIFUGMKFSA-N
- CAS 데이터베이스
- 62996-74-1
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,T,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 40-45-36/37/38-46 | ||
안전지침서 | 36/37-53-36-26-45 | ||
유엔번호(UN No.) | UN 2811 6.1 / PGII | ||
WGK 독일 | 2 | ||
F 고인화성물질 | 8-10 | ||
위험 등급 | 3 | ||
HS 번호 | 29419090 |
STAUROSPORINE C화학적 특성, 용도, 생산
개요
Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM. It inhibits rat recombinant PKC-화학적 성질
Light Yellow Solid출처
A complex alkaloid. staurosporine has been isolated from a strain of Streptomyces.용도
Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumour active, inducing apoptosis in a variety of cell lines. Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.일반 설명
A potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM), protein kinase C (IC50 = 0.7 nM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint.생물학적 활성
Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC 50 = 3 nM), protein kinase A (IC 50 = 7 nM), p 60v-src tyrosine protein kinase (IC 50 = 6 nM) and CaM kinase II (IC 50 = 20 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .STAUROSPORINE 준비 용품 및 원자재
원자재
9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2-[(3,4-dimethoxyphenyl)methyl]-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9α,10β,11β,13α)]- (9CI)
9,13-Epoxy-1H,11H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonine-1,11-dione, 2-[(3,4-dimethoxyphenyl)methyl]-2,3,9,10,12,13-hexahydro-10-methoxy-9-methyl-, 11-(O-methyloxime), [9S-(9α,10β,11Z,13α)]- (9CI)
준비 용품
STAUROSPORINE 공급 업체
글로벌( 363)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
ENBRIDGE PHARMTECH CO., LTD. | +8613812269233 |
tinayang@enbridgepharm.com | China | 302 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12446 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 |
sales@ichemie.com | China | 990 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20293 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9357 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8820 | 58 |
STAUROSPORINE 관련 검색:
1-메틸-1,3-다이하이드로이미다졸-2-싸이온 염산디펜히드라민
Succinylcholine Chloride
Staurosporine, Streptomyces sp.
STAUROSPORINE AGLYCONE
1,2,3,4-Tetrahydro Staurosporine
STAUROSPORINE,STAUROSPORINE, STREPTOMYCES SPECIES,STAUROSPORINE, STREPTOMYCES STAUROSPOREUS
ent-Staurosporine
INSTA-Blot, Apoptotic HeLa Cells, Staurosporine-Treated
INSTA-BLOT(TM), APOPTOTIC HL-60 CELLS, STAUROSPORINE-TREATED
{ STAUROSPORINE--N/H
Staurosporine, Streptomyces sp. in Solution
INSTA-BLOT(TM), APOPTOTIC HELA CELLS, STAUROSPORINE-TREATED
INSTA-BLOT(TM), APOPTOTIC JURKAT CELLS, STAUROSPORINE-TREATED
INSTA-Blot, Apoptotic Jurkat Cells, Staurosporine-Treated
JURKAT AND STAUROSPORINE LYSATE (8H),JURKAT AND STAUROSPORINE LYSATE (4H)
STAUROSPORINE READY MADE
INSTA-Blot, Apoptotic HL-60 Cells, Staurosporine-Treated