티니다졸
|
|
티니다졸 속성
- 녹는점
- 118-120?C
- 끓는 점
- 528.4±30.0 °C(Predicted)
- 밀도
- 1.4338 (rough estimate)
- 굴절률
- 1.6320 (estimate)
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 물에 거의 녹지 않으며, 아세톤과 염화메틸렌에 녹고, 메탄올에는 거의 녹지 않습니다.
- 산도 계수 (pKa)
- 2.30±0.34(Predicted)
- 색상
- 황백색에서 연한 노란색
- 최대 파장(λmax)
- 317nm(H2O)(lit.)
- Merck
- 14,9447
- BRN
- 618182
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- InChIKey
- HJLSLZFTEKNLFI-UHFFFAOYSA-N
- CAS 데이터베이스
- 19387-91-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 20/21/22-40 | ||
| 안전지침서 | 26-36 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | NI6255000 | ||
| HS 번호 | 2933290000 | ||
| 유해 물질 데이터 | 19387-91-8(Hazardous Substances Data) | ||
| 독성 | LD50 in mice (mg/kg): >3600 orally; >2000 i.p. (Miller) | ||
| 기존화학 물질 | KE-14058 |
티니다졸 C화학적 특성, 용도, 생산
화학적 성질
solid용도
Antiprotozoal (Trichomonas, Giardia); antiamebic; antibacterial.Antimicrobial activity
Its antibacterial and antiprotozoal activity is similar to that of metronidazole.The MIC against G. vaginalis is 0.2–2 mg/L; the hydroxy metabolite is significantly more active than that of metronidazole. H. pylori is inhibited by 0.5 mg/L. T. vaginalis and T. fetus at 2.5 mg/L and E. histolytica is inhibited by about 0.3–2.5 mg/L.Pharmaceutical Applications
A 5-nitroimidazole available for oral administration and, in some countries, for intravenous infusion.Mechanism of action
Tinidazole has a mechanism of action that parallels that of metronidazole as well as a similar metabolic pathway leading to hydroxylation at the 2-methyl group catalyzed by CYP3A4. Basically, tinidazole appears to mimic the actions of metronidazole, although there are reports that it is effective against some protozoa which are resistant to metronidazole.Clinical Use
Anaerobic bacterial infections(prophylaxis and treatment)Trichomoniasis
Giardiasis (single dose) Amebiasis (including amebic liver abscess)
Bacterial vaginosis
Gastric colonization with H. pylori (in combination with other agents)
부작용
Tinidazole is generally well tolerated. Infrequent and transient effects include nausea, vomiting, diarrhea and a metallic taste. Disulfiram-like reactions may occur and rare neurological disturbances and transient leukopenia have been described. Rash, which may be severe, urticaria and angioneurotic edema can occur.티니다졸 준비 용품 및 원자재
원자재
준비 용품
티니다졸 공급 업체
글로벌( 437)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12453 | 58 |
| Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5964 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +86-13474506593 +86-13474506593 |
sarah@tnjone.com | China | 794 | 58 |
| Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 |
bj1@bj-chem.com | China | 298 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2989 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8822 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 |
info@konochemical.com | China | 2995 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 |
faith@widelychemical.com | CHINA | 742 | 58 |