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Satraplatin

Satraplatin 구조식 이미지

카스 번호:: 129580-63-8

상품명:: Satraplatin

동의어(영문):: JM 216;C081294;BMY 45594;BMS 182751;SATRAPLATIN;Satraplatin(JM216);BMS-182751;BMY-45594;JM-216;bis(acetato-o)amminedichloro(cyclohexanamine)-pt;Bis-acetatoamminedichlorocyclohexylamine platinum(iv);(OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum

CBNumber:: CB2675796

분자식:: C10H20Cl2N2O4Pt

포뮬러 무게:: 498.26

MOL 파일:: 129580-63-8.mol

속성

안전

용도

공급 업체 109

Satraplatin 속성

저장 조건: Store at -20°C

용해도: DMF: 0.16 mg/mL; DMSO: 0.5 mg/mL

물리적 상태: 가루

안전

위험 및 안전 성명

독성	LD50 in mice (mg/kg): 30 i.p.; 330 orally (Kelland)

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드

예방조치문구:

NFPA 704

	0
2		0

Satraplatin C화학적 특성, 용도, 생산

용도

Antineoplastic.

정의

ChEBI: A platinum coordination entity that consists of a central platunum atom bound to chloro (x2), acetate (x2), amino, and cyclohexylamino groups. Used for treatment of advanced prostate cancer.

Pharmaceutical Applications

Satraplatin (JM216, cis,trans,cis-[PtCl2(OAc)2(NH3)(C6H5NH2)]) is a Pt(IV) or Pt4+ complex, which is active by oral administration, as it is more hydrophobic than cisplatin. This form of administration is very attractive because of the convenience and freedom it provides to the patient. Satraplatin also has a milder toxicity profile and is shows no cross-resistance with cisplatin. Satraplatin in combination with prednisone has completed phase III clinical trials against hormone-refractory prostate cancer. The results were very encouraging, but the overall survival rate did not improve significantly enough. As a result, the fast-track approval of the FDA was not granted.
Structurally, satraplatin consists of a Pt(IV) centre, which is coordinated by six ligands forming a close to octahedral geometry. In general, octahedral Pt(IV) complexes (low-spin d6) are much more kinetically inert than square planar Pt(II) complexes.

Clinical Use

This newest organometallic agent currently is in clinical trials as a second-line agent for the treatment of hormone-refractory prostate cancer . There is hope that it also will find value in ovarian cancer and small cell lung cancer.

부작용

As with other organoplatinum complexes, the diaquo form is active. At this early stage, the toxicity profile appears to be mild, with dose-related myelosuppression, particularly neutropenia and thrombocytopenia, being the major use-limiting side effect.

신진 대사

Unlike the square-planar Pt(II) complexes currently on the market, it is active by the oral route. It is metabolized quickly in whole blood, producing up to six metabolites. The major metabolite is the desacetoxy analogue.

Satraplatin 준비 용품 및 원자재

원자재

준비 용품

Satraplatin 공급 업체

글로벌( 109)공급 업체

공급자	전화	이메일	국가	제품 수	이점
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9571	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850 +86-13986145403	info@fortunachem.com	China	5985	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58

Satraplatin 관련 검색:

디사이클로헥실아민 시클로헥실아민 소듐 디클로로아세테이트 디클로로아세트산 LOBAPLATIN DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Picoplatin Eptaplatin (SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate DIBROMO(1,5-CYCLOOCTADIENE)PLATINUM(II) Glycyl-glycyl-glycine ETHYL DICHLOROACETATE trans,trans-2,4-Undecadienal Satraplatin TRANSFAT JM 221 (ammine)cyclohexylaminedichloroplatinum(II)