TEBBE REAGENT
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TEBBE REAGENT 속성
- 밀도
- 0.96 g/mL at 20 °C
- 인화점
- 34 °F
- 저장 조건
- Refrigerator
- 물리적 상태
- 액체
- 색상
- 진한 빨간색에서 보라색까지
- 수용성
- 톨루엔, 벤젠, 디클로로메탄에 용해됩니다. 물에 불용성.
- 감도
- Air & Moisture Sensitive
- Merck
- 9091
- 노출 한도
- ACGIH: TWA 20 ppm
OSHA: Ceiling 300 ppm; TWA 200 ppm
NIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3)
- InChIKey
- QEJAQNUJXFLWSP-UHFFFAOYSA-M
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | F,C | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 11-34-48/20-63-65-67 | ||
| 안전지침서 | 26-36/37/39-45-62-16 | ||
| 유엔번호(UN No.) | UN 2924 3/PG 2 | ||
| WGK 독일 | 2 | ||
| F 고인화성물질 | 1-10 | ||
| 위험 등급 | 4.3 | ||
| 포장분류 | II | ||
| HS 번호 | 29310099 |
TEBBE REAGENT C화학적 특성, 용도, 생산
화학적 성질
The Tebbe reagent is the organometallic compound with the formula (CH)TiCHClAl(CH). It is used in the methylenation of carbonyl compounds, that is it converts organic compounds containing the RC=O group into the related RC=CH derivative.It is a red solid that is pyrophoric in the air, and thus is typically handled with air-free techniques. It was originally synthesized by Fred Tebbe at DuPont Central Research. Tebbe's reagent contains two tetrahedral metal centers linked by a pair of bridging ligands. The titanium has two cyclopentadienyl ([CH]-, or Cp) rings and aluminium has two methyl groups. The titanium and aluminium atoms are linked together by both a methylene bridge (-CH-) and a chloride atom in a nearly square-planar (Ti–CH–Al–Cl) geometry.The Tebbe reagent was the first reported compound where a methylene bridge connects a transition metal (Ti) and a main group metal (Al).Preparation The Tebbe reagent is synthesized from titanocene dichloride and trimethylaluminium in toluene solution.용도
μ-Chloro-μ-methylenebis(cyclopentadienyl)titaniumdimethylaluminum is used in organic synthesis for carbonyl methylenation, A versatile methylenation reagent for the conversion of ketones and aldehydes to olefins, it offers facile reaction with hindered ketones and allows the conversion of esters to vinyl ethers. Tebbe reagent can be used to olefinate aldehydes, to methylenate a chiral polyhydroxyketone with high diasteroselctivity.일반 설명
Tebbe reagent is a Lewis acid stabilized organometallic compound, which is used to transform carbonyl groups into β-substituted methylenes. It also reacts with a wide range of carbonyl compounds, including esters, amides, and lactones to yield corresponding olefins.TEBBE REAGENT 준비 용품 및 원자재
원자재
준비 용품
TEBBE REAGENT 공급 업체
글로벌( 55)공급 업체
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