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(Z)-9-옥타데센산 1,2,3-프로판트라일 에스터

(Z)-9-옥타데센산 1,2,3-프로판트라일 에스터
(Z)-9-옥타데센산 1,2,3-프로판트라일 에스터 구조식 이미지
카스 번호:
122-32-7
한글명:
(Z)-9-옥타데센산 1,2,3-프로판트라일 에스터
동의어(한글):
(Z)-9-옥타데센산1,2,3-프로판트라일에스터;(Z)-9-옥타데센산1,2,3-프로판트라일에스터;트라이올레인
상품명:
TRIOLEIN
동의어(영문):
OLEIN;18:1TG;aldoto;raoline;TRIOLEIN;tri-olei;Erdnuoel;emery2423;TRIOLEINE;Radia 7363
CBNumber:
CB2715065
분자식:
C57H104O6
포뮬러 무게:
885.43
MOL 파일:
122-32-7.mol

(Z)-9-옥타데센산 1,2,3-프로판트라일 에스터 속성

녹는점
-5,5°C
끓는 점
235-240 °C18 mm Hg(lit.)
밀도
0.91 g/mL(lit.)
굴절률
n20/D 1.470
인화점
330 °C
저장 조건
2-8°C
용해도
chloroform: 0.1 g/mL, clear, colorless
물리적 상태
Liquid
색상
Clear Pale Yellow
Merck
14,9732
BRN
1718692
안정성
Stability Stable, but air and light sensitive. Incompatible with strong oxidizing agents.
CAS 데이터베이스
122-32-7(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 F,Xn
위험 카페고리 넘버 11-20/21/22-53
안전지침서 24/25-39-26
유엔번호(UN No.) UN 1282 3/PG 2
WGK 독일 -
RTECS 번호 RG1936500
F 고인화성물질 10-23
TSCA Yes
HS 번호 29161500
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
예방조치문구:
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.

(Z)-9-옥타데센산 1,2,3-프로판트라일 에스터 C화학적 특성, 용도, 생산

화학적 성질

colourless viscous liquid

화학적 성질

Triolein occurs as a clear, colorless to yellowish oily liquid, and is tasteless and odorless.

정의

ChEBI: A triglyceride formed by esterification of the three hydroxy groups of glycerol with oleic acid. Triolein is one of the two components of Lorenzo's oil.

생산 방법

Triolein is manufactured by the esterification of fractionated fatty acids, mainly oleic acid and glycerin.

Pharmaceutical Applications

Triolein is used as a solubilizer and solvent in injectable preparations. It has been used in marketed preparations of sustained-release injections of cytarabine and multivesicular liposomal injections of morphine sulfate. It has also been used in enteric coatings for oral preparations in combination with other enteric coating excipients to protect against degradation by pancreatic lipase.
Triolen is used in personal care products as a skin-conditioning and viscosity-controlling agent.

Safety

Triolein is used in injectable preparations, in enteric coatings for oral preparations, and in personal care products. Chronic exposure may cause nausea and vomiting, and higher exposures may cause unconsciousness.
The Cosmetic Ingredient Review (CIR) Expert Panel found that dermal application of triolein was not associated with significant irritation, and no evidence of sensitization or photosensitization was observed. Ocular exposures were found to be only mildly irritating to eyes. Triolein has not been found to be genotoxic in a number of in vitro and in vitro assay systems. Subcutaneous injections of triolein in rats showed no tumors at the injection site. The CIR Expert Panel also noted that metabolism data indicated that glyceryl triesters (including triolein) followed the same metabolic pathways as fats in food. They were split into monoglycerides, free fatty acids, and glycerol, all of which were absorbed into the intestinal mucosa and metabolized further. Therefore, oral exposure to these compounds was not found to be a concern.
A triolein-based amphotericin emulsion showed better safety with a higher LD50 in rats as compared with the conventional amphotericin deoxycholate.

저장

Triolein is classified as a stable compound but is sensitive to air and light. It should be stored in tightly sealed containers in a dry area at 2–8℃. Thermal decomposition of triolein may lead to release of irritating gases and vapors such as carbon oxides. Exposure to air and moisture over prolonged periods should be avoided.

비 호환성

Triolein is incompatible with strong oxidizing agents and spontaneously flammable products. Being a triglyceride ester, triolein can be hydrolyzed by strong acids, and particularly by strong bases. It is possible for primary amines to form an adduct across the olefinic double bonds (analogous to a Michael addition).

Regulatory Status

Included in the FDA Inactive Ingredients Database (liposomal suspension for epidural injections). Included in parenteral medicines (suspension for intrathecal injection) licensed in the UK.
Triolein is included in the CIR category as safe for use in cosmetics and personal care products. Its use as an indirect food additive has been approved by the FDA.

(Z)-9-옥타데센산 1,2,3-프로판트라일 에스터 준비 용품 및 원자재

원자재

준비 용품


(Z)-9-옥타데센산 1,2,3-프로판트라일 에스터 공급 업체

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