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황산카나마이신

황산카나마이신
황산카나마이신 구조식 이미지
카스 번호:
25389-94-0
한글명:
황산카나마이신
동의어(한글):
카나마이신,모노황산염;황산카나마이신;카나마이신,모노황산염(KANAMYCIN,MONOSULFATE)
상품명:
Kanamycin sulfate
동의어(영문):
kano;KAMYCIN;Kantrex;Kantrim;cantrex;kamynex;kanaqua;kanasig;kanicin;kantrox
CBNumber:
CB2722315
분자식:
C18H38N4O15S
포뮬러 무게:
582.58
MOL 파일:
25389-94-0.mol

황산카나마이신 속성

녹는점
250°C
알파
+112~+123°(D/20℃)(c=1,H2O)(calculated on the dried basis)
밀도
1.3619 (rough estimate)
굴절률
117.5 ° (C=1, H2O)
저장 조건
2-8°C
용해도
H2O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.
물리적 상태
powder
색상
white to off-white
pH 범위
6.5 - 8.5 (1% solution)
수용성
Soluble in water at 10mg/ml
Merck
14,5281
InChIKey
OOYGSFOGFJDDHP-KMCOLRRFSA-N
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T
위험 카페고리 넘버 61
안전지침서 22-24/25-45-53
WGK 독일 3
RTECS 번호 NZ3225030
HS 번호 29419020
독성 LD50 in mice: 20.7 g/kg orally; 1450 mg/kg i.p. (Zel'tser)
기존화학 물질 KE-21771
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H303 삼키면 유해할 수 있음 급성 독성 물질 - 경구 구분 5 P312
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 흡입 시 알레르기성 반응, 천식 또는 호흡 곤란 등을 일으킬 수 있음 호흡기 과민성 물질 구분 1 위험 P261, P285, P304+P341, P342+P311,P501
H360 태아 또는 생식능력에 손상을 일으킬 수 있음 생식독성 물질 구분 1A, 1B 위험
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P284 호흡 보호구를 착용하시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.

황산카나마이신 MSDS


Kanamycin A monosulfate

황산카나마이신 C화학적 특성, 용도, 생산

화학적 성질

Off-white powder

Originator

Kantrex,Bristol,US,1958

용도

Antibiotic complex produced by Streptomyces kanamyceticus Okami & Umezawa from Japanese soil. Comprised of three components, kanamycin A, the major component, and kanamycins B and C, two minor congeners. Antibacterial.

용도

Kanamycin sulfate is an antibacterial agent similar to neomycin.

정의

A broadspectrum antibiotic.

Manufacturing Process

As described in US Patent 2,931,798, Streptomyces kanamyceticus (K2-J) was first cultured in shake flasks in the following media: (a) 0.75% meat extract, 0.75% peptone, 0.3% NaCl, with 1.0% of starch, dextrin, maltose, glucose, lactose, sucrose or glycerol; or (b) 2.0% soybean meal, 0.05% KCl, 0.05% MgSO4 · 7H2O, 0.5% NaCl, 0.2% NaNO3, with 1.0% of starch, dextrin, maltose, glucose, lactose, sucrose or glycerol. The initial pH of all media was adjusted to 7.0. After 24 to 48 hours shaking in some cases the pH decreased to about 6.0 to 6.8, but from 72 to 120 hours the pH rose and became 7.5 to 8.6. The production of kanamycin was apparent after 48 hours and, depending on the media; the maximum production was found after 72 to 120 hours.
The yield was highest with starch or dextrin, intermediate and about the same with sucrose, glucose, maltose and lactose and poorest with glycerol. Kanamycin was produced by media containing soybean meal, peanut meal, cottonseed meal, corn steep liquor, peptone, yeast extract or meat extract, with or without sodium nitrate. Commercially available soybean meal was recognized to be one of the best nitrogen sources. The addition of corn steep liquor, peptone, yeast extract or nitrate to the soybean meal promoted the production of kanamycin.
The brownish white kanamycin (5 g) was dissolved in 50 ml of 60% aqueous methanol, insoluble material was removed and to the filtrate 40 ml of 60% aqueous methanol containing 2,000 mg of ammonium sulfate was added, and the precipitated kanamycin sulfate was collected, washed with 50 ml of 80% aqueous methanol, and dried. Thus, 4.5 g of kanamycin sulfate was obtained as a light brownish powder.

상표명

Klebcil (King).

Therapeutic Function

Antibacterial

황산카나마이신 준비 용품 및 원자재

원자재

준비 용품


황산카나마이신 공급 업체

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