겐타미신 황산염
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겐타미신 황산염 속성
- 녹는점
- 218-237°C
- 알파
- D25 +102°
- 밀도
- 1.000 g/cm3
- 저장 조건
- 2-8°C
- 용해도
- H2O: 50 mg/mL 원액으로 '20°C에 보관하세요. 37°C에서 5일 동안 안정합니다.
- 물리적 상태
- 가루
- 색상
- 무색~연황색
- 수소이온지수(pH)
- 4.0-5.5 (0.1g/mL in H2O)
- 냄새
- 냄새 없는
- optical activity
- [α]20/D +110±8°, c = 1% in H2O
- 수용성
- 물에 용해됨
- Merck
- 13,4403
- InChIKey
- RDEIXVOBVLKYNT-HDZPSJEVSA-N
- CAS 데이터베이스
- 1405-41-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 42/43 | ||
안전지침서 | 23-36/37-45-22-24/25 | ||
WGK 독일 | 2 | ||
RTECS 번호 | LY2625000 | ||
F 고인화성물질 | 3 | ||
HS 번호 | 29419010 | ||
독성 | LD50 in mice (mg base/kg): 430 i.p.; 485 s.c.; 75 i.v.; >9050 orally (Black) | ||
기존화학 물질 | KE-17593 |
겐타미신 황산염 C화학적 특성, 용도, 생산
화학적 성질
White to buff-colored powder, hygroscopic, easily soluble in water, insoluble in lipids, insoluble in organic solvents, stable in chemical properties, relatively stable to changes in temperature and pH, the pH of 4% aqueous solution is 4.0-6.0. There are five basic centers in the gentamicin molecule, which is a basic compound, and the drug is the sulfate of gentamicin. Gentamicin is a complex of C components, the main components of which are C1, C2, C1a, and C2a.용도
Gentamicin sulfate is an aminoglycoside antibiotic. Inhibits protein synthesis by binding to L6 protein of 50S ribosomal subunit. Antibacterial. Antibiotic complex consists of three closely related components, gentamicins C1, C2, C1a, and also gentamicin A which differs from the other members of the complex but is similar to Kanamycin C. Gentamicin C1: R1=R2=CH3 Gentamicin C2: R1=CH3; R2=H Gentamicin C1A: R1=R2=H.일반 설명
Gentamicin sulfate is a sulfate salt of an antibiotic complex produced by fermentation of Micromonospora purpurea or M. echinospora. There are three components, each consisting of five basic nitrogens and requiresing five equivalents of sulfuric acid per mole of gentamicin base. Three closely related components that are chemically amino-saccharides. White to buff-colored powder. pH (4% solution) 3.5 to 5.5. Odorless.공기와 물의 반응
Water soluble. Hygroscopic.반응 프로필
Gentamycin sulfate is very stable in solution, even in moderately acidic to strongly basic aqueous media.화재위험
Flash point data for Gentamycin sulfate are not available; however, Gentamycin sulfate is probably combustible.Safety Profile
Poison by intravenous, intraperitoneal, and intramuscular routes. Moderately toxic by subcutaneous route. Human systemic effects: level changes for metals other than Na/K/Fe/Ca/P/Cl. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx. See also other gentamycin entries.참고 문헌
Schroeder et al (2000) Modulation of RNA function by aminoglycoside antibiotics. EMBO.J. 4 1. PMID: 10619838.Casemore (1967) Gentamicin as a bactericidal agent in virological tissue cultures. J.Clin.Pathol. 20 298. PMID: 4972293
Martin, N.L., et al. Gentamicin interaction with Pseudomonas aeruginosa cell envelope. J. Comp. Neurol. 1986, 29(6), 1079-1087. DOI:10.1128/AAC.29.6.1079
Kadurugamuwa, J.L., et al. Surface action of gentamicin on Pseudomonas aeruginosa. J. Bacteriol. 1993, 175(18), 5798-805. DOI:10.1128/jb.175.18.5798-5805.1993
겐타미신 황산염 준비 용품 및 원자재
원자재
암모니아수
탄산칼슘
말토덱스트린
아밀라아제
염화 암모늄
코발트 염화물, 헥사수화물
염산
황산철(Ⅱ)
수산화나트륨
감자전분
질산나트륨
황산마그네슘
펩톤
황산마그네슘(7수화물)
황산
암모니아(가스)
질산칼륨
SOYBEAN MEAL
준비 용품
겐타미신 황산염 공급 업체
글로벌( 749)공급 업체
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