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페로스 푸마레이트

페로스 푸마레이트
페로스 푸마레이트 구조식 이미지
카스 번호:
141-01-5
한글명:
페로스 푸마레이트
동의어(한글):
페로스푸마레이트;페로스푸마레이트;페러스푸마레이트
상품명:
Ferrous fumarate
동의어(영문):
firon;fumar;ircon;galfer;cpiron;ferrone;fumafer;fumar-f;hemoton;palafer
CBNumber:
CB2739933
분자식:
C4H2FeO4
포뮬러 무게:
169.9
MOL 파일:
141-01-5.mol

페로스 푸마레이트 속성

녹는점
>280°C
밀도
2.435
용해도
Slightly soluble in water, very slightly soluble in ethanol (96 per cent).
물리적 상태
solid
수용성
Soluble in water (0.14 g/100 ml at 25°C).
Merck
14,4046
안정성
Stability
InChIKey
PMVSDNDAUGGCCE-TYYBGVCCSA-L
CAS 데이터베이스
141-01-5(CAS DataBase Reference)
EPA
2-Butenedioic acid (2E)-, iron(2+) salt (1:1) (141-01-5)

안전

위험 카페고리 넘버 36/37/38
안전지침서 22-36/37/39-24/25
WGK 독일 2
RTECS 번호 LT1950000
TSCA Yes
HS 번호 29171900
독성 LD50 in mice, rats (mg Fe/kg): 630, 580 orally (Berenbaum)
기존화학 물질 KE-03969

페로스 푸마레이트 MSDS


Iron(II) fumarate

페로스 푸마레이트 C화학적 특성, 용도, 생산

개요

Ferrous fumarate is the ferrous salt form of fumarate. One of its most important applications is being used as iron supplements for the treatment of iron deficiency and anemia. It has been demonstrated that application of ferrous sulfate drops or a single daily dose of microencapsulated ferrous fumarate sprinkles plus ascorbic acid both result in successful treatment of anemia without remarkable side effects. However, recent studies have also shown that compared to other iron supplements, ferrous fumarate has a highest rate of inducing adverse reactions such as erosive mucosal injury in the gastrointestinal tract as well as nausea, vomiting and epigastric discomfort.

화학적 성질

brown to reddish-brown powder

화학적 성질

§184.1307d(a) Ferrous fumarate (iron(II)fumarate, C4H2Fe04) is an odorless, reddish-orange to reddish-brown powder. It may contain soft lumps that produce a yellow streak when crushed. It is prepared by admixing hot solutions of ferrous sulfate and sodium fumarate.

Originator

Toleron,Mallinckrodt Inc.,US,1957

용도

Ferrous fumarate is available as a syrup and may be useful in small children for the treatment and prophylaxis of iron deficiency.

용도

Ferrous Fumarate is a reddish orange to red-brown powder that is a source of iron. it has high bioavailability and can be used in foods where the red color can be masked. it contains approximately 33% iron. it is used as a dietary supplement in breakfast cereals, poultry stuffing, enriched flour, and instant drinks.

정의

Anhydrous salt of a combination of ferrous iron and fumaric acid, stable, odorless, substantially tasteless. Reddish-brown, anhydrous powder, contains 33% iron by weight, does not melt at temperatures up to 280C, insoluble in alcohol, very slightly solubl

Manufacturing Process

Sodium carbonate (53.5 pounds of Na2CO3-H2O) was dissolved in water (40 to 45 gallons) and fumaric acid (50 pounds) was added slowly. During the addition the solution was stirred and heated. The resulting solution of sodium fumarate, having a pH of 6.8, was added slowly with mixing to a solution of ferrous sulfate (118 pounds FeSO4-7H2O in 33 gallons of water) having a pH of 3.3, both solutions being maintained at or near boiling temperature during the mixing. The resulting slurry of reddish-brown anhydrous ferrous fumarate was filtered and washed in a centrifuge and dried in a tray drier (15 hours at 110°C). Yield: 63 pounds, 86% of theory. Calculated for FeC4H2O4: Fe, 32.9%. Found: Fe, 32.6%. Only 0.2% of ferric iron (Fe+++) was found.

Therapeutic Function

Hematinic

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: dyspnea, nausea or vomiting, somnolence. When heated to decomposition it emits acrid smoke and irritating fumes. See also FUMRIC ACID.

참고 문헌

Zlotkin, Stanley, et al. "Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods." The American journal of clinical nutrition 74.6 (2001): 791-795.
Cancelo-Hidalgo, María Jesús, et al. "Tolerability of different oral iron supplements: a systematic review." Current medical research and opinion 29.4 (2013): 291-303.

페로스 푸마레이트 준비 용품 및 원자재

원자재

준비 용품


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