Pirprofen
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Pirprofen 속성
- 녹는점
- 98-100°
- 끓는 점
- 410.8±45.0 °C(Predicted)
- 밀도
- 1.1778 (rough estimate)
- 굴절률
- 1.5270 (estimate)
- 저장 조건
- -20°C Freezer, Under inert atmosphere
- 용해도
- DMSO (약간 용해됨), 에틸아세테이트 (약간 용해됨), 메탄올 (약간 용해됨)
- 용해도
- DMSO(약간 용해됨), 에틸아세테이트(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 4.56±0.10(Predicted)
- 색상
- 회백색
안전
| 기존화학 물질 | KE-05608 |
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Pirprofen C화학적 특성, 용도, 생산
용도
Pirprofen is a non-steroidal anti-inflammatory drug.World Health Organization (WHO)
Pirprofen, a nonsteroidal anti-inflammatory agent, was introduced in 1982 primarily for the treatment of rheumatic diseases, as well as for use in posttraumatic and post-operative inflammatory conditions, acute gout and dysmenorrhoea. Reports of serious adverse effects, in particular cases of liver toxicity, some of which were fatal, led the manufacturer, in 1985 and in 1989, to amend the approved product information of the drug, limiting duration of treatment and lowering the recommended doses. In the light of these successive restrictions, which have considerably reduced the field of application of pirprofen and in view of available alternatives, the manufacturer has decided to discontinue the drug worldwide.Synthesis
Synthesis: treatment of the sodium salt of diethyl methylmalonate with 2,4- dichloronitrobenzene yields diethyl (3-chloro- 4-nitrophenyl)methylmalonate. Saponification, decarboxylation, and subsequent reesterification followed by catalytic reduction gives ethyl 4-amino-3-chloro-α-methylbenzeneacetate hydrochloride. Treatment of the latter with 1,4- dichloro-2-butene in the presence of sodium carbonate followed by saponification affords pirprofen.
Pirprofen 준비 용품 및 원자재
원자재
준비 용품
Pirprofen 공급 업체
글로벌( 11)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29220 | 58 |
| Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan pengyin Pharmaceutical Co., Ltd | 13163333255 |
1939328613@qq.com | China | 395 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 |
marketing@energy-chemical.com | China | 44941 | 58 |
| Baoji Didu Pharmaceutical and Chemical Co., Ltd | 029-61856358 15829046862 |
1035@dideu.com | China | 10011 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 |
market@aladdin-e.com | China | 48617 | 58 |