2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol

2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol C화학적 특성, 용도, 생산

Originator

Esucos,UCB Chemie,W. Germany,1962

Manufacturing Process

To a suspension of sodamide in liquid ammonia and made from sodium in liquid ammonia, there is added fractionally and with stirring phenothiazine. After an hour there is added thereto, while maintaining the stirring, 1-chloro- 2-methyl-3-bromopropane, then 700 cc of toluene. The ammonia is then driven off and heating under reflux is carried out for one hour.
After cooling, water is added and the solution then decanted. The toluene phase is then evaporated in vacuo to constant weight. The residue is constituted of 10-(2-methyl-3-chloro-propyl)-phenothiazine containing acertain quantity of phenothiazine which has not reacted. As this product is not readily soluble in petroleum ether, it is possible to eliminate it by extraction by means of this solvent.
By operating in this manner 10-(2-methyl-3-chloro-propyl)phenothiazine is obtained. A mixture of l0-(2-methyl-3-chloro-propyl)phenothiazine and 1-[2- (2-hydroxyethoxy)ethyl]piperazine is then heated at 110°-120°C for 20 hours. After cooling, the reaction product is dissolved in 200 cc of benzene and the solution washed several times with water.
The benzene phase is then extracted by dilute hydrochloric acid. The acid aqueous phase is decanted, it is made distinctly alkaline and then extracted with benzene. The benzene extract is dried and evaporated in vacuo. The condensation product could not be crystallized. It may be converted into the dihydrochloride which, after recrystallization from isopropanol, melts at 192°C.

Therapeutic Function

Tranquilizer

2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol 준비 용품 및 원자재

원자재

준비 용품

2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Changzhou PBpharmaceutical R&D Co.,Ltd	0519-83990708	info@pbpharm.com	CHINA	498	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58
Changzhou PBpharmaceutical R&D Co.,Ltd	0519-83990708	lxy2046@yeah.net	China	480	55
Aikon International Limited	025-66028182 18112977050	cfzhang@aikonchem.com	China	15820	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 15801484223	psaitong@jm-bio.com	China	29834	58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd	17691182729 18161915376	1046@dideu.com	China	10008	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58
https://hanhongsci.com/	021-54306202 18917919676	info@hanhongsci.com	China	29989	58

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