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Icaritin

Icaritin 구조식 이미지

카스 번호:: 118525-40-9

상품명:: Icaritin

동의어(영문):: ICARITIN;Icaritin>Icaritin, >98%;Icaritin(Anhydroicaritin);Icariin Impurity 3(Icaritin);Icariin Impurity 2 (Icaritin);3,7-bis(2-hydroxyethyl)icaritin;3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one;3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one,3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-

CBNumber:: CB2982508

분자식:: C21H20O6

포뮬러 무게:: 368.38

MOL 파일:: 118525-40-9.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 224

Icaritin 속성

녹는점: 239℃

끓는 점: 582.0±50.0 °C(Predicted)

밀도: 1.359

인화점: 206.7℃

저장 조건: 2-8°C

용해도: DMSO: 용해성5mg/mL, 투명(가온)

물리적 상태: 가루

산도 계수 (pKa): 6.44±0.40(Predicted)

색상: 연한 노란색에서 진한 노란색까지

최대 파장(λmax): 368nm(MeOH)(lit.)

InChI: InChI=1S/C21H20O6/c1-11(2)4-9-14-15(22)10-16(23)17-18(24)19(25)20(27-21(14)17)12-5-7-13(26-3)8-6-12/h4-8,10,22-23,25H,9H2,1-3H3

InChIKey: TUUXBSASAQJECY-UHFFFAOYSA-N

SMILES: C1(C2=CC=C(OC)C=C2)OC2=C(C/C=C(/C)\C)C(O)=CC(O)=C2C(=O)C=1O

안전

WGK 독일	3
RTECS 번호	DJ3100870
HS 번호	29329990

Icaritin C화학적 특성, 용도, 생산

화학적 성질

Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from epimedium.

용도

Icaritin is a hydrolytic product of Icariin, a traditional Chinese herbal medicine extracted from the Epimedium genus. Icaritin and Desmethylicaritin, is two metabolites of Icariin, dramatically inhibit the growth of most malignant cells. They also have significant antiangiogenesis properties, inhibiting or eliminating entirely the development of new malignant cells. Icaritin has been used in trials studying the treatment of Solid Tumors, Metastatic Breast Cancer, and Hepatocellular Carcinoma (HCC).

Synthesis

The novel total synthesis of icaritin, naturally occurring with important bioactive 8-prenylflavonoid, was performed via a reaction sequence of 8 steps including Baker-Venkataraman reaction, chemoselective benzyl or methoxymethyl protection, dimethyldioxirane (DMDO) oxidation, O-prenylation, Claisen rearrangement and deprotection, starting from 2,4,6-trihydroxyacetophenone and 4-hydroxybenzoic acid in overall yields of 23%. The key step was Claisen rearrangement under microwave irradiation.
Total Synthesis of Icaritin via Microwave-assistance Claisen Rearrangement

Mode of action

Icaritin is a flavonoid first isolated from the Chinese herb H. epimedii that demonstrates anticancer activity against a variety of tumor cell lines. Icaritin was shown in vitro to sustain extracellular signal–regulated kinase (ERK) activity through stimulating estrogen receptors. Prolonged ERK activation arrested the cell cycle in the G2 stage and subsequently triggered apoptosis. It has been shown to inhibit fatty acid synthase, reducing IGF-1-induced activation of STAT3 in several melanoma cell lines.

Icaritin 준비 용품 및 원자재

원자재

Icaritin Icariin Icariside I baohuoside I KAEMPFEROLTETRAACETATE 디메틸설페이트

준비 용품

Desmethylanhydroicaritin

Icaritin 공급 업체

글로벌( 224)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+8618829768577	gao490372054@gamil.com	China	1250	58
PNP Biotech Co. Ltd	+8618516098983	sales@pnpbiotech.com	China	1001	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+86-19164747840 +86-13119157289	13119157289@163.com	China	2971	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	+86-18580541567 +86-17782035140	sales@zhswyy.com	China	338	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7786	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58

Icaritin 관련 검색:

시코닌 페이민 아스트라갈린 파클리탁셀 노다케닌 Baohuoside V (+/-)-Naringenin Quercetin Epimedium Extract Icariin epimedoside A 4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-8-(3-hydroxy-3-methylbutyl)-2-(4-methoxyphenyl)- Genipin Icariside I 13,14-Didehydromatridin-15-one Catalpol Cabazitaxel Anhydroicaritin