핀도롤
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핀도롤 속성
- 녹는점
- 167-171 °C(lit.)
- 끓는 점
- 391.39°C (rough estimate)
- 밀도
- 1.0606 (rough estimate)
- 굴절률
- 1.5110 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 0.1M NaOH: 0.2mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- pKa 9.26 (Uncertain)
- 색상
- 흰색에서 황백색까지
- 수용성
- 33mg/L(22.5 ºC)
- Merck
- 13,7525
- CAS 데이터베이스
- 13523-86-9(CAS DataBase Reference)
- NIST
- Pindolol(13523-86-9)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-36/37/38 | ||
| 안전지침서 | 26-36 | ||
| 유엔번호(UN No.) | 3249 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | UB6660000 | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| HS 번호 | 2933995300 | ||
| 유해 물질 데이터 | 13523-86-9(Hazardous Substances Data) | ||
| 독성 | LD50 oral in rabbit: 650mg/kg |
핀도롤 C화학적 특성, 용도, 생산
화학적 성질
White Solid용도
Pindolol, like nadolol, is a nonselective β-adrenoblocker. It possesses antianginal, antihypotensive, and antiarrythmic action. It is used for arterial hypertension, angina stress (preventing attacks), supraventricular tachycardia, tachsystolic form of atrial fibrillation, and superventricular extrasystole.정의
ChEBI: A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.생물학적 활성
5-HT 1A/1B ? receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β 3 -adrenoceptors.신진 대사 경로
Several metabolites of pindolol formed in vitro are detected after a 24 h incubation of human hepatocytes in both pure culture and co-culture by adding rat liver epithelial cells. The hepatocytes are able to oxidize the isopropyl amine moiety and the pyrrole ring of the indole moiety and conjugate pindolol as sulfates and glucuronides.신진 대사
Pindolol (Visken) is extensively absorbed from the gastrointestinal tract. First-pass metabolism is estimated at about 15%, and its plasma half-life is on the order of 3 to 4 hours.The binding of pindolol to plasma proteins is approximately 50%.The metabolic fate of pindolol is not completely understood, although 50% of an administered dose is recovered, primarily in the urine, as unchanged drug.핀도롤 준비 용품 및 원자재
원자재
준비 용품
핀도롤 공급 업체
글로벌( 92)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 |
info@afinechem.com | CHINA | 15377 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9339 | 58 |
| CD Chemical Group Limited | +8615986615575 |
info@codchem.com | China | 20356 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49739 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43348 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33349 | 58 |
핀도롤 관련 검색:
트리스(하이드록시메틸)아미노메탄 인돌-3-아세트산 6-아미노 카프로산 글리신 인돌 인드메타신 1-프로판올 핀도롤
Methoxydiethylborane
ALTRENOGEST
(-)-INDOLACTAM V
4-Hydroxyindole
1-Chloro-3-(1H-indol-4-yloxy)-2-propanol
teoprolol
4-[3-[(1,1-DIMETHYLETHYL)AMINO]-2-HYDROXYPROPOXY]-1H-INDOLE-2-CARBOXYLIC ACID, 1-METHYLETHYL ESTER
Bopindolol
CARAZOLOL HCL
rac Mepindolol-d7