Siccanin

Siccanin 구조식 이미지
카스 번호:
22733-60-4
상품명:
Siccanin
동의어(영문):
Siccanin;Sicanina;Siccanine;NSC 135048;Siccaninum;CS 280, SI 23548;Siccanin USP/EP/BP;Sicanina [inn-spanish];Siccanine [inn-french];1,2,3,4,4a,5,6,6a,11b,13b-Decahydro-4,4,6a,9-tetramethyl-13H-benzo[a]furo[2,3,4-mn]xanthen-11-ol
CBNumber:
CB31120733
분자식:
C22H30O3
포뮬러 무게:
342.47
MOL 파일:
22733-60-4.mol

Siccanin 속성

녹는점
139-140°
알파
D20 -136° (c = 2 in chloroform)
끓는 점
427.8±45.0 °C(Predicted)
밀도
1.18±0.1 g/cm3(Predicted)
저장 조건
Store at -20°C
용해도
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
물리적 상태
고체
산도 계수 (pKa)
10.9(at 25℃)

안전

독성 LD50 in mice, rats (mg/kg): >6000, >1000 orally; >3000, >600 s.c. or i.p. (Suzuki)
기존화학 물질 KE-09390

Siccanin C화학적 특성, 용도, 생산

개요

Siccanin is an inhibitor of mitochondrial complex II (succinate dehydrogenase; IC50s = 0.87 and 9.3 μM for P. aeruginosa and rat mitochondria, respectively). It inhibits the growth of T. mentagrophytes (IC50 = 0.3 μg/ml) via inhibition of succinate oxidation in the mitochondria. It also inhibits the growth of C. albicans strains with IC50 values ranging from 5-40 and 80-90 μg/ml for aerobic and anaerobic conditions, respectively.

용도

Siccanin is an unusual, fused, phenolic pentacycle first isolated from Helminthosporium siccans and reported in 1962 as a potent antifungal agent. Siccanin inhibits succinate dehydrogenase in the terminal electron transport system. More recent studies note the proximity of the siccanin binding site to the quinone-binding site of the enzyme. Species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors and offers a lead for new chemotherapeutics.

Origin

Siccanin was found in the culture broth of Helminthosporium siccans by Sankyo Co. in 1962.

Siccanin 준비 용품 및 원자재

원자재

준비 용품


Siccanin 공급 업체

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