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코우마린

코우마린
코우마린 구조식 이미지
카스 번호:
91-64-5
한글명:
코우마린
동의어(한글):
쿠마린;코우마린
상품명:
Coumarin
동의어(영문):
Rattex;CUMARIN;Kumarin;COUMARIN;NSC 8774;ncic07103;COUMARINE;NCI C07103;AKOS 212-75;COUMARIN(P)
CBNumber:
CB3112168
분자식:
C9H6O2
포뮬러 무게:
146.14
MOL 파일:
91-64-5.mol

코우마린 속성

녹는점
68-73 °C(lit.)
끓는 점
298 °C(lit.)
밀도
0.935
증기압
0.01 mm Hg ( 47 °C)
굴절률
1.5100 (estimate)
인화점
162 °C
저장 조건
Refrigerator
용해도
1.7g/l
물리적 상태
Crystals or Crystalline Powder
색상
White
pH 범위
Non' uorescence (9.5) to light green ' uorescence (10.5)
수용성
1.7 g/L (20 ºC)
최대 파장(λmax)
275nm
Merck
14,2562
BRN
383644
주요 응용
color filter, organic electroluminescent devices, liquid crystal displays, field emission displays, inks, nickel plating, detergents, deodorant for shoes, petroleum products, cigarettes, personal care products, cosmetics, sunscreen cream, perfumes, nucleic acid sequencing, antiinflammatory agent, treatment of cancer, neurotransmission disorders, bleeding disorders, cerebrovascular disease, thrombosis, hemorrhoids, rheumatic disease, arthritic disease, epilepsy, vaginitis, painkiller, teeth whitening agent, skin whitening agent, wound healing promoter
InChIKey
ZYGHJZDHTFUPRJ-UHFFFAOYSA-N
CAS 데이터베이스
91-64-5(CAS DataBase Reference)
NIST
Coumarin(91-64-5)
EPA
2H-1-Benzopyran- 2-one(91-64-5)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 22-40-36/37/38-20/21/22-43
안전지침서 36-36/37-26
유엔번호(UN No.) UN 2811 6.1/PG 3
WGK 독일 1
RTECS 번호 GN4200000
TSCA Yes
위험 등급 6.1
포장분류 III
HS 번호 29322010
유해 물질 데이터 91-64-5(Hazardous Substances Data)
독성 LD50 orally in rats, guinea pigs: 680, 202 mg/kg (Jenner)
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 P264, P270, P301+P310, P321, P330,P405, P501
H351 암을 일으킬 것으로 의심됨 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

코우마린 C화학적 특성, 용도, 생산

화학적 성질

WHITE CRYSTALS OR CRYSTALLINE POWDER

화학적 성질

Coumarin occurs widely in nature and determines, for example, the odor of woodruff. It forms white crystals (mp 70.6°C) with a hay-like, spicy odor. When treated with dilute alkali, coumarin is hydrolyzed to the corresponding coumarinic acid salt [(Z)-2-hydroxycinnamic acid]. Heating with concentrated alkali or with sodium ethanolate in ethanol results in the formation of o-coumaric acid salts [(E)-2-hydroxycinnamic acid]. 3,4-Dihydrocoumarin is obtained by catalytic hydrogenation, for example, with Raney nickel as a catalyst; octahydrocoumarin is obtained if hydrogenation is carried out at high temperature (200–250°C).

화학적 성질

Coumarin has a sweet, fresh, hay-like, odor similar to vanilla seeds, and a burning taste with bitter undertone and nutlike flavor on dilution.

용도

coumarin is considered a blood thinner, it can also increase blood flow. Some sources cite anti-oxidant capacities, as well. It is a specific plant constituent and is what creates the fragrance of freshly mowed hay. Coumarin is found in such plants as cherries, lavender, licorice, and sweet clover.

용도

Pharmaceutic aid (flavor). Found in tonka beans, levender oil, woodruff, sweet clover.

용도

antineoplastic, antiinflammatory, antihyperglycaemic

정의

ChEBI: A chromenone having the keto group located at the 2-position.

제조 방법

Coumarin is currently produced by Perkin synthesis from salicylaldehyde. In the presence of sodium acetate, salicylaldehyde reacts with acetic anhydride to produce coumarin and acetic acid. The reaction is carried out in the liquid phase at elevated temperature.
A process for the production of coumarin from hexahydrocoumarin by dehydrogenation has also been elaborated.
Since the odor of coumarin is relatively weak, strong-smelling by-products (e.g., vinylphenol) must be removed. Many purification methods have been reported and patented.

정의

A colorless crystalline compound with a pleasant odor, used in making perfumes. On hydrolysis with sodium hydroxide it forms coumarinic acid.

Aroma threshold values

Detection at 34 to 50 ppb; recognition, 250 ppb

일반 설명

Colorless crystals, flakes or colorless to white powder with a pleasant fragrant vanilla odor and a bitter aromatic burning taste.

공기와 물의 반응

Insoluble in water.

반응 프로필

Coumarin is sensitive to exposure to light. Coumarin is also sensitive to heat. Coumarin is incompatible with strong acids, strong bases and oxidizers. Coumarin is hydrolyzed by hot concentrated alkalis. Coumarin can be halogenated, nitrated and hydrogenated (in the presence of catalysts).

위험도

Toxic by ingestion; carcinogenic. Use in food products prohibited (FDA). Questionable carcinogen.

건강위험

SYMPTOMS: Exposure to Coumarin may cause narcosis. It may also cause irritation and liver damage.

화재위험

Coumarin is combustible.

색상 색인 번호

Coumarin is an aromatic lactone naturally occurring in Tonka beans and other plants. As a fragrance allergen, it has to be mentioned by name in cosmetics within the EU

Safety Profile

Poison by ingestion, intraperitoneal, and subcutaneous routes. Questionable carcinogen with experimental tumorigenic data. Experimental teratogenic effects. Mutation data reported. Combustible when exposed to heat or flame. When heated to decomposition it emits acrid smoke and fumes. See also KETONES and ANHYDRIDES.

Chemical Synthesis

May be extracted from tonka beans; from salicylaldehyde and acetic anhydride in the presence of sodium acetate; also from o-cresol and carbonyl chloride followed by chlorination of the carbonate and fusion with a mixture of alkali acetate, acetic anhydride and a catalyst.

Purification Methods

Coumarin crystallises from ethanol or water and sublimes in vacuo at 43o [Srinivasan & deLevie J Phys Chem 91 2904 1987]. [Beilstein 17/10 V 143.]

코우마린 준비 용품 및 원자재

원자재

준비 용품


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18017610038
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career henan chemical co
+86-371-86658258
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+86 18953170293
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Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2258 58

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