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4-(4-Aminophenoxy)-N-methylpicolinamide

4-(4-Aminophenoxy)-N-methylpicolinamide 구조식 이미지

카스 번호:: 284462-37-9

상품명:: 4-(4-Aminophenoxy)-N-methylpicolinamide

동의어(영문):: 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide;4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide;SL-M2;Sorafen;Sorafenib INT2;Sorafenib impurity A;Sorafenib Intermediate;Sorafenib tosylate INT III;Sorafenib Related Compound 23;[4-(4-Aminophenoxy-2-pyridyl)]

CBNumber:: CB31175425

분자식:: C13H13N3O2

포뮬러 무게:: 243.26

MOL 파일:: 284462-37-9.mol

속성

안전

용도

공급 업체 419

4-(4-Aminophenoxy)-N-methylpicolinamide 속성

녹는점: 110-112°C

끓는 점: 476.8±40.0 °C(Predicted)

밀도: 1.241±0.06 g/cm3(Predicted)

증기압: 0.001-0.05Pa at 20-109.84℃

저장 조건: Keep in dark place,Inert atmosphere,Room temperature

용해도: DMSO(약간 용해됨), 메탄올(약간 용해됨)

산도 계수 (pKa): 13.96±0.46(Predicted)

색상: White to Light yellow to Light orange

LogP: 0.9 at 25℃ and pH7

표면장력: 71.71mN/m at 883.8mg/L and 20.1℃

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험 등급	IRRITANT
HS 번호	2933399990

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고		P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고		P264, P280, P305+P351+P338,P337+P313P

예방조치문구:

P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.

4-(4-Aminophenoxy)-N-methylpicolinamide C화학적 특성, 용도, 생산

화학적 성질

Light-Brown Solid

용도

Sorafenib intermediate

Synthesis

To a solution of 4-aminophenol (1 g, 9.2 mmol) in DMF (20 mL) was added 1M potassium ier/-butoxide in THF (9.7 mL, 9.7 mmol) at room temperature. After 2h, (4-chloro(2-pyridyl))-N- methyl carboxamide (1.6 g, 9.2 mmol) and potassium carbonate (0.64 g, 4.6 mmol) were added, and then the reaction mixture was heated to 80 °C for 6h. After cooling, the reaction mixture was extracted with ethyl acetate (50 mL). The organic layer was washed with brine (20 mL) and dried over magnesium sulfate. The solvent was removed in vacuo. The residue was purified by column chromatography to afford 4-(4-Aminophenoxy)-N-methylpicolinamide (2.2 g, 80 %) as a light-brown solid.

4-(4-Aminophenoxy)-N-methylpicolinamide 준비 용품 및 원자재

원자재

준비 용품

N-Methyl-4-(4-(3-(trifluoroMethyl)benzaMido)phenoxy)picolinaMide Tosylate Sorafenib

4-(4-Aminophenoxy)-N-methylpicolinamide 공급 업체

글로벌( 419)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Henan Alfa Chemical Co., Ltd	+8618339805032	alfa4@alfachem.cn	China	12755	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7613	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	885	50
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60

4-(4-Aminophenoxy)-N-methylpicolinamide 관련 검색:

피콜린아미드 N,N-다이메틸폼아마이드 노르말메틸포름아미드 Sorafenib Impurity 35 Sorafenib Impurity 43 1-(4-chloro-3-(trifluoromethyl)phenyl)urea Trimebutine maleate Sorafenib SORAFENIB N-OXIDE Sorafenib tosylate N-Methyl-4-chloropyridine-2-carboxamide 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine 1,4-Benzoquinoneimine Sorafenib related compound 10 4-HYDROXYPHENYLFORMAMIDE Sorafenib Related Compound 21 Sorafenib related coMpound 8 Sorafenib IMpurity