4-Chloro-4'-fluorobutyrophenone
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4-Chloro-4'-fluorobutyrophenone 속성
- 녹는점
- 5-6 °C
- 끓는 점
- 130-132 °C (0.97513 mmHg)
- 밀도
- 1.22 g/mL at 25 °C(lit.)
- 굴절률
- n
20/D 1.5255(lit.)
- 인화점
- >230 °F
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- 클로로포름(소량으로 용해), 에틸아세테이트(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 기름
- 색상
- 약간 황록색 투명함
- 수소이온지수(pH)
- 4.05 at 23.1℃ and 10g/L
- 수용성
- 0.38g/L(20℃)
- BRN
- 608741
- InChIKey
- HXAOUYGZEOZTJO-UHFFFAOYSA-N
- LogP
- 2.84 at 30℃
- CAS 데이터베이스
- 3874-54-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-36/37/38-20/21/22 | ||
| 안전지침서 | 24/25-36-26 | ||
| WGK 독일 | 3 | ||
| 위험 참고 사항 | Irritant | ||
| TSCA | Yes | ||
| HS 번호 | 2914790090 |
4-Chloro-4'-fluorobutyrophenone C화학적 특성, 용도, 생산
화학적 성질
slightly yellow-greenish clear oil용도
4-Chloro-4''-fluorobutyrophenone (cas# 3874-54-2) is a compound useful in organic synthesis.Synthesis
The purified alkyne (5 mmol) was treated with a solution of HNTf2 (60-200 mol %) in 1,4-dioxane in apreheated oil bath at 100°C, under magnetic stirring, for 18-52 h, and the corresponding ketone was purified by column chromatography after cooling 4-Chloro-4'-fluorobutyrophenone. The reaction crude was purified by column chromatography using 20% AcOEt in n-hexane as an eluent. Isolated yield: 850 mg (85%). R f (20% AcOEt in n-hexane): 0.66. GC-MS (m/ z, M+? 200), major peaks found: 200 (1%), 164 (1%), 138 (43%), 123 (100%), 107 (10%). 1H NMR (δ, ppm; J, Hz): 8.03-7.97 (2C-H arom, mult), 7.17-7.09 (2C-H arom, mult), 3.68 (CH2, t, J = 6.2), 3.15 (CH2, t, J = 7.0), 2.22 (CH2, tt, J = 7.0, 6.2). 13C NMR (δ, ppm; J, Hz): 197.3 (C=O), 166.1 (C, d, J 1 C-F = 254.7), 133.2 (C, d, J 4 C-F = 4.3), 130.6 (2CH, d, J 3 C-F = 9.3), 115.9 (2CH, d, J 2 C-F = 22.2), 44.6 (CH2), 35.2 (CH2), 26.7 (CH2).
4-Chloro-4'-fluorobutyrophenone 준비 용품 및 원자재
원자재
준비 용품
4-Chloro-4'-fluorobutyrophenone 공급 업체
글로벌( 392)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 |
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| Shanghai Famo Biotech Co Ltd | +86-36680037 +86-18550473860 |
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| Dorne Chemical Technology co. LTD | +86-13583358881 +86-18560316533 |
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| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
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| Shandong Hanjiang Chemical Co., Ltd | +86-0533-2066820 +8618369939125 |
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| Wuhan Xinhao Biotechnology Co., Ltd | +86-18120578002 +86-18120578002 |
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| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
4-Chloro-4'-fluorobutyrophenone 관련 검색:
2-부타논 옥심 에피클로로하이드린 메틸이소부틸케톤 2,3,5,6-테트라플루오로벤질 트랜스-2-(2,2-디클로로비닐)-3,3-디메틸사이클로프로판카르복실레이트 플루오르벤젠알데히드 페닐노르말프로필케톤 클로로아세트산 클로로디플루오르메탄
Florfenicol
N-(4'-fluorobutyrophenone)-4-(4-chlorophenyl)pyridinium
4-[4-(4-chloro-2,3,5,6-tetradeuteriophenyl)-4-hydroxy-1-oxidopiperidin-1-ium-1-yl]-1-(4-fluorophenyl)butan-1-one
GUTXTARXLVFHDK-GIVHGBEGSA-N
Haloperidol EP Impurity E
4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(3-ethyl-4-fluorophenyl)-1-butanone
3-CHLORO-4'-FLUOROPROPIOPHENONE
HALOPERIDOL RELATED COMPOUND A (15 MG) (4,4'-BIS[(4-P-CHLOROPHENYL)-4-HYDROXY-PIPERIDINO]-BU-TYROPHENONE)
Dechloro Haloperidol (Haloperidol Impurity B)
Cyclopropyl 4-fluorophenyl ketone