ACONINE

ACONINE 구조식 이미지
카스 번호:
509-20-6
상품명:
ACONINE
동의어(영문):
ACONINE;Aconitysat;Jesaconine;ACONINE USP/EP/BP;Aconine (Jesaconine);20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13...;20-Ethyl-1α,6α,16β-trimethoxy-4-(methoxymethyl)aconitane-3α,8,13,14α,15α-pentol;(15S,16S)-20-Ethyl-1α,6α,16-trimethoxy-4-(methoxymethyl)aconitane-3α,8β,13β,14α,15-pentol;Aconitane-3,8,13,14,15-pentol,20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, (1a,3a,6a,14a,15a,16b)-;Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, (1α,3α,6α,14α,15α,16β)-
CBNumber:
CB31229467
분자식:
C25H41NO9
포뮬러 무게:
499.6
MOL 파일:
509-20-6.mol

ACONINE 속성

녹는점
129-131℃
알파
D +23°
끓는 점
590.79°C (rough estimate)
밀도
1.42
굴절률
1.6000 (estimate)
저장 조건
-20°C Freezer
용해도
클로로포름 (약간 용해됨), DMSO (약간 용해됨)
산도 계수 (pKa)
9.52(at 25℃)
물리적 상태
고체
물리적 상태
단단한 모양
색상
황백색에서 연한 노란색

안전

ACONINE C화학적 특성, 용도, 생산

개요

Aconine is an alkaloid originally isolated from Aconitum species and active metabolite of aconitine. It inhibits osteoclast differentiation of RANKL-stimulated RAW 264.7 cells and bone resorption in a pit formation assay in a concentration-dependent manner. Aconine also inhibits RANKL-induced activation of NF-κB and NFATc1 in RAW 264.7 cells. In vivo, aconine is toxic to mice when administered intravenously at a dose of 120 mg/kg. It induces flaccid paralysis and toxicity in rats with toxic dose (TD50) and LD50 values of 1.5 and 1.7 μmol per animal, respectively.

ACONINE 준비 용품 및 원자재

원자재

준비 용품


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