2,2-bis(4-fluorophenyl)-2-phenyl-acetamide
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2,2-bis(4-fluorophenyl)-2-phenyl-acetamide 속성
- 녹는점
- 180-181 °C(Solv: hexane (110-54-3); dichloromethane (75-09-2))
- 끓는 점
- 460.7±45.0 °C(Predicted)
- 밀도
- 1.250±0.06 g/cm3(Predicted)
- 저장 조건
- Sealed in dry,Store in freezer, under -20°C
- 용해도
- DMSO : 50 mg/mL (154.64 mM; Need ultrasonic)
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 15.41±0.50(Predicted)
안전
2,2-bis(4-fluorophenyl)-2-phenyl-acetamide C화학적 특성, 용도, 생산
개요
Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels. It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (; IC50s = 11 and 30 nM, respectively). Senicapoc (10 mg/kg twice per day) reduces IKCa1/KCa3.1 channel activity, increases potassium levels in RBCs, and decreases erythrocyte density in the SAD transgenic mouse model of sickle cell disease. It inhibits IL-2, IFN-γ, IL-12, and IL-17A production in CD3+ T cells stimulated with phorbol 12-myristate 13-acetate (PMA; ) and ionomycin (Item Nos. 10004974 | 11932) when used at a concentration of 1 μM. Senicapoc (100 mg/kg) increases the paw withdrawal threshold in a rat model of chronic constriction injury (CCI) of the sciatic nerve.용도
Treatment of disorders mediated by a calcium activated intermediate conductance potassium ion channel antagonist.2,2-bis(4-fluorophenyl)-2-phenyl-acetamide 준비 용품 및 원자재
원자재
준비 용품
2,2-bis(4-fluorophenyl)-2-phenyl-acetamide 공급 업체
글로벌( 78)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 7838 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23556 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 |
info@finetechnology-ind.com | China | 9571 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9339 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |