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D-판텐올

D-판텐올
D-판텐올 구조식 이미지
카스 번호:
81-13-0
한글명:
D-판텐올
동의어(한글):
D-판텐올;판테놀;덱스판테놀
상품명:
Dexpanthenol
동의어(영문):
Cozyme;Ilopan;Pantol;Urupan;Proleus;Motilyn;Panadon;synapan;Bepantol;Intrapan
CBNumber:
CB3169304
분자식:
C9H19NO4
포뮬러 무게:
205.25
MOL 파일:
81-13-0.mol

D-판텐올 속성

녹는점
64~69℃
알파
30.5 º (c=5, H2O on anh. sub)
끓는 점
118-120 °C (2.7 mmHg)
밀도
1.20 g/mL at 20 °C (lit.)
굴절률
1.495-1.502
인화점
118-120°C/0.02m
저장 조건
2-8°C
물리적 상태
Viscous Liquid or Semi Solid
산도 계수 (pKa)
13.03±0.20(Predicted)
색상
Clear colorless to slightly yellow
수소이온지수(pH)
pH (100g/l,25℃) : 8.5~10.5
optical activity
[α]20/D +30±1°, c = 5% in H2O
수용성
soluble
감도
Hygroscopic
Merck
14,2947
BRN
1724947
InChIKey
SNPLKNRPJHDVJA-ZETCQYMHSA-N
CAS 데이터베이스
81-13-0(CAS DataBase Reference)
NIST
Dexpanthenol(81-13-0)
EPA
(+)-Panthenol (81-13-0)

안전

위험품 표기 Xn
위험 카페고리 넘버 36/37/38-48-41-37/38-20/21/22
안전지침서 23-24/25-45-36/37/39-26-22
WGK 독일 1
RTECS 번호 ES4316000
F 고인화성물질 3-10
TSCA Yes
HS 번호 29241990
유해 물질 데이터 81-13-0(Hazardous Substances Data)
독성 LD50 oral in mouse: 15gm/kg
기존화학 물질 KE-10837

D-판텐올 MSDS


(+)-Panthenol

D-판텐올 C화학적 특성, 용도, 생산

화학적 성질

clear colorless to slightly yellow viscous liquid

Originator

Bepanthene,Roche,France,1951

용도

cholinergic

용도

D-Panthenol is an analogue of pantothenic acid (P190300), a member of the B complex vitamins. D-Panthenol is the biologically active enantiomer of Panthenol.

용도

immunosuppressant, mitoxantrone analogue less toxic on cardiac tissue antineoplastic

Manufacturing Process

130 parts by weight of d(-)-α-hydroxy-β,β-dimethyl-gamma-butyric acid lactone are dissolved in 150 parts by volume of methyl alcohol. 75 parts by weight of 3-hydroxypropylamine are added, in one portion, to the solution and the mixture is well stirred. While the reaction sets in, the temperature of the mixture gradually rises by itself to about 50°C and then drops again after about two hours. To cause completion of the reaction, the mixture is allowed to stand at room temperature for 24 hours. The so obtained (d+)-α,γdihydroxy-β,β-dimethyl-butyric-acid-(3'-hydroxypropyl)-amide is freed from methyl alcohol in vacuo. It is a colorless, viscous oil, easily soluble in water. It boils under a pressure of 0.02 mm between 118° and 120°C.

상표명

D-Panthenol 50 (BASF); Ilopan (Savage); Motilyn (Abbott).

Therapeutic Function

Gastrointestinal drug

색상 색인 번호

Pan(to)thenol is the alcohol corresponding to pantothenic acid, of the vitamin B5 group. It is used as a food additive, and in skin and hair products as a conditioning agent. Contact dermatitis and urticaria have been reported.

Safety Profile

Moderately toxic by intravenous route. A skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx. See also AMIDES.

Veterinary Drugs and Treatments

Dexpanthenol has been suggested for use in intestinal atony or distension, postoperative retention of flatus and feces, prophylaxis and treatment of paralytic ileus after abdominal surgery or traumatic injuries, equine colic (not due to mechanical obstruction) and any other condition when there is an impairment of smooth muscle function. Controlled studies are lacking with regard to proving the efficacy of the drug for any of these indications.

Purification Methods

Purify D-panthenol by distillation in vacuo. It is a slightly hygroscopic viscous oil and is soluble in H2O and organic solvents. It is hydrolysed by alkali and strong acid. [Rabin J Am Pharm Assoc (Sci Ed) 37 502 1948, Bonati & Pitré Farmaco Ed Scient 14 43 1959, Beilstein 4 IV 1652.]

D-판텐올 준비 용품 및 원자재

원자재

준비 용품


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