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Econazole nitrate

Econazole nitrate 구조식 이미지
카스 번호:
24169-02-6
상품명:
Econazole nitrate
동의어(영문):
Pargin;Amicel;Micogin;Gynoryl;SQ 13050;Micofugal;e Nitrate;NSC 243115;Gyno-Pevaril;Gyno-prevaryl
CBNumber:
CB3173103
분자식:
C18H16Cl3N3O4
포뮬러 무게:
444.7
MOL 파일:
24169-02-6.mol

Econazole nitrate 속성

녹는점
162°C
저장 조건
Inert atmosphere,Room Temperature
용해도
chloroform/methanol: soluble25mg/mL (choloroform:methanol (1:1))
물리적 상태
powder
색상
white to off-white
수용성
<0.1 g/100 mL at 19 ºC
Merck
14,3502
InChIKey
DDXORDQKGIZAME-UHFFFAOYSA-N
CAS 데이터베이스
24169-02-6(CAS DataBase Reference)
EPA
Econazole mononitrate (24169-02-6)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,Xi
위험 카페고리 넘버 22-36/38-36/37/38
안전지침서 26-36-36/37
WGK 독일 3
RTECS 번호 NI4450000
HS 번호 29332900
독성 LD50 in mice, rats (mg/kg): 462.7, 667.7 orally (Thienpont)
기존화학 물질 KE-05843
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P321 (…) 처치를 하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P332+P313 피부 자극이 생기면 의학적인 조치· 조언을 구하시오.

Econazole nitrate MSDS


1-(2,4-Dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)imidazole nitrate

Econazole nitrate C화학적 특성, 용도, 생산

화학적 성질

White to Off-White Solid

Originator

Pevaryl,Cilag Chemie,France,1976

용도

Antifungal;Ergosterol synthesis inhibition

용도

Azole antifungal

용도

Econazole nitrate is an antifungal agent of the imidazole type used in topical and vaginal preparations to prevent growth of dermatophytes, yeast, and mold.

Manufacturing Process

A suspension of 10.3 parts of α-(2,4-dichlorophenyl)-imidazole-1-ethanol and 2.1 parts of sodium hydride in 50 parts of dry tetrahydrofuran is stirred andrefluxed for 2 hours. After this reaction-time, the evolution of hydrogen is ceased. Then there are added successively 60 parts dimethylformamide and 8 parts of p-chlorobenzylchloride and stirring and refluxing is continued for another two hours. The tetrahydrofuran is removed at atmospheric pressure. The dimethylformamide solution is poured onto water. The product, 1-[2,4- dichloro-β-(p-chlorobenzyloxy)phenethyl]imidazole, is extracted with benzene. The extract is washed with water, dried, filtered and evaporated in vacuo. From the residual oily free base, the nitrate salt is prepared in the usual manner in 2-propanol by treatment with concentrated nitric acid, yielding, after recrystallization of the crude solid salt from a mixture of 2-propanol, methanol and diisopropylether, 1-[2,4-dichloro-β-(pchlorobenzyloxy)phenethyl]imidazole nitrate; MP 162°C.

상표명

Spectazole (Johnson & Johnson).

Therapeutic Function

Antifungal

일반 설명

White crystalline powder.

공기와 물의 반응

Insoluble in water.

화재위험

Flash point data for Econazole nitrate are not available; however, Econazole nitrate is probably combustible.

Econazole nitrate 준비 용품 및 원자재

원자재

준비 용품


Econazole nitrate 공급 업체

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Target Molecule Corp
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