Boc-N-methyl-L-leucine

Boc-N-methyl-L-leucine 구조식 이미지
카스 번호:
53363-89-6
상품명:
Boc-N-methyl-L-leucine
동의어(영문):
Tyr(Me);BOC-MELEU-OH;BOC-LEU(ME)-OH;BOC-L-MELEU-OH;BOC-ALA(TBU)-OH;BOC-N-ME-LEU-OH;BOC-N-ME-LEUCINE;Boc-N-Me-L-Leu-OH;BOC-BETA-TBU-ALA-OH;BOC-BETA-TBU-ALANINE
CBNumber:
CB3197622
분자식:
C12H23NO4
포뮬러 무게:
245.32
MOL 파일:
53363-89-6.mol

Boc-N-methyl-L-leucine 속성

녹는점
55-60 °C
끓는 점
338.2±21.0 °C(Predicted)
밀도
1.053±0.06 g/cm3(Predicted)
저장 조건
Sealed in dry,2-8°C
산도 계수 (pKa)
4.04±0.21(Predicted)
optical activity
[α]20/D 36±2°, c = 1% in methylene chloride
BRN
2373250
InChI
InChI=1S/C12H23NO4/c1-8(2)7-9(10(14)15)13(6)11(16)17-12(3,4)5/h8-9H,7H2,1-6H3,(H,14,15)/t9-/m0/s1
InChIKey
YXJFAOXATCRIKU-VIFPVBQESA-N
SMILES
C(O)(=O)[C@H](CC(C)C)N(C(OC(C)(C)C)=O)C
CAS 데이터베이스
53363-89-6(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
WGK 독일 3
HS 번호 2924 19 00
위험 등급 IRRITANT
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고 GHS hazard pictograms
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

Boc-N-methyl-L-leucine C화학적 특성, 용도, 생산

개요

Boc-N-methyl-L-leucine is the BOC (tert-butyloxycarbonyl) protected N-methylated leucine. The N-methylated amino acid is quite useful in the peptide synthesis, giving a lot of improved properties to peptide. Studies have shown that peptide containing N-methylated amino acids obtain increased proteolytic stability, increased membrane permeability, and altered conformation. The effects of N-methylated amino acids are quite important in the development of therapeutic peptide compound as well as in the assay of biological activity of some modified peptides. BOC group can be easily removed by treatment with strong acids such as trifluoroacetic acid.

생물학적 활성

Boc-N-methyl-L-leucine is a peptidyl nucleobase that has been shown to inhibit tumor cell growth and induce tumor regression in animal models. It is an amide of leucine and the antibiotic aminouracil, which is a guanine analogue. Boc-N-methyl-L-leucine has also shown to inhibit tumor growth by inhibiting mitochondrial membrane potential, which may lead to cell death in cancer cells. This compound has been shown to be effective against both solid tumors and leukemia cell lines. Boc-N-methyl-L-leucine also inhibits the proliferation of human prostate cancer cells by blocking the synthesis of nucleic acids and proteins.

참고 문헌

https://en.wikipedia.org/wiki/Tert-Butyloxycarbonyl_protecting_group
http://pubs.acs.org/doi/abs/10.1021/cr030024z?src=recsys&journalCode=chreay

Boc-N-methyl-L-leucine 준비 용품 및 원자재

원자재

준비 용품


Boc-N-methyl-L-leucine 공급 업체

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Capot Chemical Co.,Ltd.
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Alpha Biopharmaceuticals Co., Ltd
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ATK CHEMICAL COMPANY LIMITED
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Hubei xin bonus chemical co. LTD
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Sichuan Jiaying Lai Technology Co.,LTD
18716376478
ycling@enlaibio.com CHINA 302 58
Alchem Pharmtech,Inc.
8485655694
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CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 47465 58
Jinan Honest Pharm Co., Ltd
+8615318812076
zpy8217@163.com China 286 58

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