enniatin A1

enniatin A1 구조식 이미지
카스 번호:
4530-21-6
상품명:
enniatin A1
동의어(영문):
enniatin A1;2-(N-Methyl-L-valine)enniatin A;(3S,6R,9S,12R,15S,18R)-3,9-bis[(2S)-butan-2-yl]-4,10,16-trimethyl-6,12,15,18-tetra(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone;Cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl]
CBNumber:
CB32079106
분자식:
C35H61N3O9
포뮬러 무게:
667.879
MOL 파일:
4530-21-6.mol

enniatin A1 속성

녹는점
116-117 °C
끓는 점
840.5±65.0 °C(Predicted)
밀도
1.027±0.06 g/cm3(Predicted)
저장 조건
-20°C
용해도
DMSO: 용해성10mg/mL
물리적 상태
백색 내지 황백색의 결정성 고체.
산도 계수 (pKa)
-1.44±0.70(Predicted)

안전

위험품 표기 T
위험 카페고리 넘버 23/24/25
안전지침서 45
유엔번호(UN No.) 2811
WGK 독일 3
위험 등급 6.1(a)
포장분류 I

enniatin A1 C화학적 특성, 용도, 생산

용도

Enniatins are a family of depsipeptide ionophores, produced several Fusarium species. More recently, the effects of the ennitins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumour action have received more focus. Enniatin A1 is one of four major analogues of the enniatin complex and has previously not been available for investigation.

정의

ChEBI: An enniatin obtained from formal cyclocondensation of one N-[(2R)-2-hydroxy-3-methylbutanoyl]-N-methyl-L-valine and two N-[(2R)-2-hydroxy-3-methylbu anoyl]-N-methyl-L-isoleucine units.

Biochem/physiol Actions

Enniatins are a group of cyclohexadepsipeptide mycotoxins produced by Gnomonia errabuda and several Fusaria species, with phytotoxic, antibiotic, and insecticidal activities. Enniatins function as ionophors by their incorporation into the cellular membrane to form dimeric structures that transport monovalent ions across the membrane (especially the mitochondrial membranes) affecting oxidative phosphorylation uncoupling. It has been demonstrated that enniatins have a cytotoxic effect on human cancer cells. Furthermore, incubation of H4IIE hepatoma cells with enniatins strongly diminished phosphorylation of the ERK (p44/p42).

enniatin A1 준비 용품 및 원자재

원자재

준비 용품


enniatin A1 공급 업체

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