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lubiprostone

lubiprostone 구조식 이미지
카스 번호:
333963-40-9
상품명:
lubiprostone
동의어(영문):
UR-021;Spi 0211;Lubiprostone;Unii-7662kg2R6k;Lubiprostone-d4;Ruby prostaglandin;AMitiza Lubiprostone;Lubiprostone (Ring Closed);Lubiprostone (Mixture of Tautomeric Isomers);Prostan-1-oic acid, 11,15-epoxy-16,16-difluoro-15-hydroxy-9-oxo-, (11alpha,15R)-
CBNumber:
CB32129504
분자식:
C20H32F2O5
포뮬러 무게:
390.46
MOL 파일:
333963-40-9.mol

lubiprostone 속성

끓는 점
532.3±50.0 °C(Predicted)
밀도
1.175
산도 계수 (pKa)
4.77±0.10(Predicted)

안전

lubiprostone C화학적 특성, 용도, 생산

개요

Chronic constipation is an affliction affecting 4–5 million Americans alone. When no specific cause is identified, it is classified as idiopathic. Dietary and lifestyle modifications are the first-line conventional approaches followed by the administration of laxatives. Unfortunately, chronic idiopathic constipation is frequently refractory to traditional therapy; thus, the need for novel agents exists. Lubiprostone is a bicyclic fatty acid with a novel mechanism of action. Without affecting sodium and potassium ion concentrations, lubiprostone activates intestinal chloride ion channels, thereby, increasing intestinal water secretion and intestinal fluid chloride ion concentration. In basolateral membranepermeabilized T84 gastrointestinal epithelial cells under chloride gradient conditions, lubiprostone concentration-dependently increased short-circuit current with an EC50 of approximately 20 nM.

Originator

Sucampo (US)

상표명

Amitiza

일반 설명

This product is marketed as Amitiza bySucampo Pharmaceuticals, Inc. and Takeda PharmaceuticalsAmerica, Inc. to relieve chronic idiopathic constipation inadults. The recommended oral dosage is 24 μg 2 times a daywith food. Precautions and side effects are similar to thosefor other prostaglandin-derived products.

lubiprostone 준비 용품 및 원자재

원자재

준비 용품


lubiprostone 공급 업체

글로벌( 98)공급 업체
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Shanghai finete Pharmaceutical Co., Ltd.
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- sales@finetechpharm.com CHINA 139 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21791 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22631 55
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28235 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47484 58
career henan chemical co
0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 24473 58
Watson International Ltd. 86-0512-81863996
86-512-81867260/70/80-3; +44 (0)20 360 89 360-31-9 contact@watson-int.com China 14914 58
Jinan elephant international trading co., LTD
- 13006575422@163.com China 6357 58

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