포타슘아세설팜

포타슘아세설팜 속성

포타슘아세설팜 C화학적 특성, 용도, 생산

순도시험

  (1) 불소화물 : 이 품목 1g을 정밀히 달아 「구연산칼슘」의 순도시험 (8)에 따라 시험한다(3ppm 이하).

  (2) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 1.0ppm 이하이어야 한다.

  (3) 기타 자외선흡수물질 : 이 품목 1g을 정밀히 달아 물에 녹여 100mL로 한 것을 시험용액으로 하고, 이 액 20μL를 다음의 조작조건으로 액체크로마토그래피프에 주입하여 다음의 시험방법에 따라 시험한다. 주피크 유지시간의 3배 시간 이내에 다른 피크가 나타날 때에는 시험용액을 물로 50,000배로 희석한 액 20μL를 다시 주입하여 시험한다. 시험용액에서 얻은 주피크 유지시간의 3배 시간 이내에 있는 주피크 이외의 모든 피크의 면적 합계가 시험용액을 물로 50,000배로 희석한 액을 측정한 주피크의 면적보다 높아서는 아니 된다(아세설팜칼륨으로서 20ppm 이하).

    조작조건

      검 출 기 : UV 227nm

      칼    럼 : 3～5μm ODS(4.6mm×250mm) 또는 이와 동등한 것

      이 동 상 : 아세토니트릴․0.01mol/L 황산수소테트라부틸암모늄(tetrabutyl ammonium hydrogen sulfate)의 혼액 (40 : 60)

      유    속 : 1mL/min

  칼럼은 이 품목 10mg 및 「파라옥시안식향산에틸」 10mg을 각각 달아 물에 녹여 혼액으로 하고 다시 물을 가해 1,000mL로한 액의 20μL를 상기 조건으로 액체크로마토그래피에 주입하였을 때, 두 피크가 서로 분리되는 것을 사용한다.

확인시험

  (1) 이 품목 10mg에 물 1,000mL를 가해 녹인 액은 파장 225～229nm에 극대흡수부가 있다.

  (2) 이 품목은 확인시험법 중 칼륨염의 반응을 나타낸다.

  (3) 이 품목 0.2g에 초산(30→100) 2mL 및 물 2mL를 가하여 녹인 다음 코발티아질산나트륨시액 수 방울을 가하면 황색의 침전을 나타낸다.

정량법

이 품목을 건조한 다음 약 0.15g을 정밀히 달아 초산 50mL를 가하여 녹이고 0.1N 과염소산용액으로 적정한다(지시약 : 크리스탈바이올렛․빙초산시액 1mL). 다만, 종말점은 청록색이 30초 이상 지속될 때로 한다. 따로 같은 방법으로 공시험을 행하여 보정한다.

0.1N 과염소산용액 1mL = 20.12mg C₄H₄KNO₄S

화학적 성질

Acesulfame potassium occurs as a colorless to white-colored, odorless, crystalline powder with an intensely sweet taste.

역사

Acesulfame-K, the potassium salt of acesulfame, is a sweetener that resembles saccharin in structure and taste profile. 5,6-Dimethyl-1,2,3-oxathiazine-4(3H)-one 2,2-dioxide, the first of many sweet compounds belonging to the dihydrooxathiazinone dioxide class, was discovered accidentally in 1967. From these many sweet compounds, acesulfame was chosen for commercialization. To improve water solubility, the potassium salt was made. Acesulfame-K (Sunett) was approved for dry product use in the United States in 1988 and in Canada in October, 1994. In 2003, acesulfame-K was approved as a general purposes sweetener by the FDA.

용도

'New generation', heat-stable sweetener that has not been suspected to cause cancer nor be genotoxic. Allelic variation of the Tas1r3 gene affects behavioral taste responses to this molecule, suggesting that it is a T1R3 receptor ligand.

생산 방법

Acesulfame potassium is synthesized from acetoacetic acid tertbutyl ester and fluorosulfonyl isocyanate. The resulting compound is transformed to fluorosulfonyl acetoacetic acid amide, which is then cyclized in the presence of potassium hydroxide to form the oxathiazinone dioxide ring system. Because of the strong acidity of this compound, the potassium salt is produced directly.
An alternative synthesis route for acesulfame potassium starts with the reaction between diketene and amidosulfonic acid. In the presence of dehydrating agents, and after neutralization with potassium hydroxide, acesulfame potassium is formed.

상표명

Sunett? and Sweet One?

Pharmaceutical Applications

Acesulfame potassium is used as an intense sweetening agent in cosmetics, foods, beverage products, table-top sweeteners, vitamin and pharmaceutical preparations, including powder mixes, tablets, and liquid products. It is widely used as a sugar substitute in compounded formulations,and as a toothpaste sweetener.
The approximate sweetening power is 180–200 times that of sucrose, similar to aspartame, about one-third as sweet as sucralose, one-half as sweet as sodium saccharin, and about 4-5 times sweeter than sodium cyclamate.It enhances flavor systems and can be used to mask some unpleasant taste characteristics.

Safety Profile

When heated to decompositionemits toxic fumes of SOx.

Safety

Acesulfame potassium is widely used in beverages, cosmetics, foods, and pharmaceutical formulations, and is generally regarded as a relatively nontoxic and nonirritant material. Pharmacokinetic studies have shown that acesulfame potassium is not metabolized and is rapidly excreted unchanged in the urine. Long-term feeding studies in rats and dogs showed no evidence to suggest acesulfame potassium is mutagenic or carcinogenic.
The WHO has set an acceptable daily intake for acesulfame potassium of up to 15 mg/kg body-weight.The Scientific Committee for Foods of the European Union has set a daily intake value of up to 9 mg/kg of body-weight.
LD₅₀ (rat, IP): 2.2 g/kg
LD₅₀ (rat, oral): 6.9–8.0 g/kg

저장

Acesulfame potassium possesses good stability. In the bulk form it shows no sign of decomposition at ambient temperature over many years. In aqueous solutions (pH 3.0–3.5 at 208℃) no reduction in sweetness was observed over a period of approximately 2 years. Stability at elevated temperatures is good, although some decomposition was noted following storage at 408℃ for several months. Sterilization and pasteurization do not affect the taste of acesulfame potassium.
The bulk material should be stored in a well-closed container in a cool, dry place and protected from light.

Regulatory Status

Included in the FDA Inactive Ingredients Database for oral and sublingual preparations. Included in the Canadian List of Acceptable Non-medicinal Ingredients. Accepted for use in Europe as a food additive. It is also accepted for use in certain food products in the USA and several countries in Central and South America, the Middle East, Africa, Asia, and Australia.

포타슘아세설팜 준비 용품 및 원자재

원자재

준비 용품

포타슘아세설팜 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Across Biotech Jinan Co LTD	+8613031735486	frank@acrossbiotech.com	China	105	58
Shanghai Affida new material science and technology center	+undefined15081010295	2691956269@qq.com	China	359	58
airuikechemical co., ltd.	+undefined86-15315557071	sales02@airuikechemical.com	China	994	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+86-13474506593 +86-13474506593	sarah@tnjone.com	China	794	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9352	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2989	55
Shanxi Naipu Import and Export Co.,Ltd	+86-13734021967 +8613734021967	kaia@neputrading.com	China	1011	58

포타슘아세설팜 관련 검색: