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lannaconitine

lannaconitine 구조식 이미지

카스 번호:: 32854-75-4

상품명:: lannaconitine

동의어(영문):: LAPPACONITINE;Lannaconitine;Aconitum extract;(+)-Lappacontine;(+)-Lappaconitine;N-Acetylpuberanidine;(+)-Lappaconitine >90%;Giant Typhonium Rhizome;Aconitum kusnezoffii Reichb;acetyl-10-deoxysepaconitine

CBNumber:: CB3235290

분자식:: C32H44N2O8

포뮬러 무게:: 584.7

MOL 파일:: 32854-75-4.mol

속성

안전

MSDS

용도

공급 업체 202

lannaconitine 속성

녹는점: 217-218°

알파: D18 +27° (chloroform)

끓는 점: 641.72°C (rough estimate)

밀도: 1.1897 (rough estimate)

굴절률: 1.6260 (estimate)

저장 조건: Store at 2-8°C, protect from light

용해도: Chloroform: 30 mg/ml

물리적 상태: 고체

산도 계수 (pKa): 12.55±0.70(Predicted)

안정성: 흡습성

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

독성	LD50 in mice (mg/kg): 6.9 i.v.; 9.1 i.p.; approx 20 orally (Dybing)

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H300	삼키면 치명적임	급성 독성 물질 - 경구	구분 1,2	위험		P264, P270, P301+P310, P321, P330,P405, P501

예방조치문구:

P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P270	이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P310	삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P321	(…) 처치를 하시오.
P330	입을 씻어내시오.
P405	밀봉하여 저장하시오.
P501	...에 내용물 / 용기를 폐기 하시오.

NFPA 704

	0
3		0

lannaconitine MSDS

(1a,14a,16b)-20-Ethyl-1,14,16-trimethoxyaconitane-4,8,9-triol 4-(2-acetylamino)benzoate)

lannaconitine C화학적 특성, 용도, 생산

개요

A highly toxic aconitine alkaloid present in Aconitum leucostomum and A. septentrionale Koelle, lappaconitine crystallizes in hexagonal tablets for whichtwo melting points have been recorded. It has [α]_D + 22.3° (C6H6) or [α]¹⁸_D + 27.0° (CHC1 3). The early view that a methylimino group is present has been shown to be erroneous. No crystalline salts are known but the diacetyl derivative forms colourless crystals, m.p. l25-7°C. The base is only sparingly soluble in H20 and most organic solvents, but dissolves readily in CHC1 3.
Boiling the alkaloid with dilute H2S04 in a stream of H2 yields acetic acid and anthranoyllappaconine, C30H4207N2, which forms colourless rhombic tablets, m.p. 146-9°C;[α]²⁵_D + 22.07° (C6H6), giving a platinichloride tetrahydrate as brown needles, m.p. 300-31 O°C (dec.). When hydrolyzed with HCl, the base furnishes acetic and anthranilic acids and lappaconine, m.p. 96°C; [α]²⁵_D + 22.41°, giving a crystalline hydrochloride, m.p. 246-7°C and the aurichloride monohydrate, m.p. l26-7°C. Alkaline hydrolysis, on the other hand, furnishes lappaconine and lappaconitic acid (acetylanthranilic acid). From these observations, it is clear that only one hydroxyl group is associated with an acyl group in the molecule.
Pharmacologically, lappaconitine is toxic although its action is less pronounced than that of aconitine (q.v.). Toxic doses produce respiratory paralysis and have a direct action upon the heart often terminating in ventricular fibrillation.

참고 문헌

Schultze, Ulfert., Arch. Pharrn., 260,230 (1922)
Weidemann., Chern. Zentr., 1,603 (1923)
Khaimova et al., Tetrahedron Lett., 2711 (1964)
Structure:
Tel'nov, Yunusov, Yunusov., Khirn. Prir. Soedin., 6, 583 (1970)
Pharmacology:
Rosendahl., quoted by Boehm,!. BioI. Chern., 170,203 (1947)

lannaconitine 준비 용품 및 원자재

원자재

준비 용품

lannaconitine 공급 업체

글로벌( 202)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7613	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+86-13474506593 +86-13474506593	sarah@tnjone.com	China	864	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	3000	58

lannaconitine 관련 검색:

아코니틴 벤조산, 2-아미노-, 2-메틸프로필 에스터 L-Hyoscyamine Xanthiazone veratramine Xanthiside daurisoline (1a,14a,16b)-20-Ethyl-1,14,16-trimethoxyaconitane-4,8,9-triol 4-(2-(acetylamino)benzoate) hydrobromide N-deacetyllappaconitine DECYL ANTHRANILATE 1-[(dimethylamino)methyl]-1-methylpropyl benzoate lannaconitine tert-Butyl 2-aminobenzoate iso-amylanthranilate 4-Benzoyloxycyclohexanol 3-(BENZYLOXY)PIPERIDINE CYCLOHEXYL ANTHRANILATE 3-Piperidinol,1,2,3-trimethyl-