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트라메티닙

트라메티닙
트라메티닙 구조식 이미지
카스 번호:
871700-17-3
한글명:
트라메티닙
동의어(한글):
트라메티닙
상품명:
Trametinib
동의어(영문):
CS-30;100836;TraMetinib;CB32514557;GSK-1120212;TraMetinib API;QuMei iMatinib;Trametinib, >=98%;Trametinib Impurity;Trametinib free base
CBNumber:
CB32514557
분자식:
C26H23FIN5O4
포뮬러 무게:
615.3947932
MOL 파일:
871700-17-3.mol

트라메티닙 속성

녹는점
300-301 °C
밀도
1.74
물리적 상태
White solid.
산도 계수 (pKa)
14.76±0.70(Predicted)

안전

안전지침서 24/25
HS 번호 29339900

트라메티닙 C화학적 특성, 용도, 생산

용도

Used in the systematic treatment of advanced cutaneous melanoma. An EGFR kinase inhibitor.

용도

antiprotozoal

정의

ChEBI: A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment.

Indications

MEK, also known as MAPK, is a dual specificity threonine/tyrosine kinase that is a key node in the Raf–Ras–MEK signaling pathway. Small-molecule MEK inhibitors represent the largest group of type III allosteric inhibitors that do not bind to the ATP binding pocket. As of December 2016, besides the FDA-approved MEK1/2 inhibitors trametinib (Mekinist(R), GlaxoSmithKline) and cobimetinib (Cotellic(R), Roche), over 10 MEK inhibitors are currently in clinical trials. Trametinib was approved by FDA in 2013 for the treatment of patients with either B-Raf V600E or V600K mutated metastatic melanoma. Considering the fact that MEK and Raf are different kinases along the same pathway of Ras–Raf–MEK/ERK signaling cascade, combination strategies using both MEK and B-Raf inhibitors were utilized to overcome the observed progression using single-agent trametinib, which usually occurs within 7months. FDA approved the combination of trametinib and dabrafenib for the treatment of B-Raf V600E/K mutated metastatic melanoma in January 2014 and the combination of cobimetinib and vemurafenib for the same type of indication. Although significant improvement in progression-free survival was observed using MEK/B-Raf combination strategy, the incidence of some common adverse effects, such as vomiting, diarrhea, nausea, rash, and pyrexia, also increased.

트라메티닙 준비 용품 및 원자재

원자재

준비 용품


트라메티닙 공급 업체

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ATK CHEMICAL COMPANY LIMITED
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+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24886 60
career henan chemical co
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sales@coreychem.com CHINA 30039 58
Biochempartner
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