1,1,1,3,3,3-헥사플루오로-2-프로판올
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1,1,1,3,3,3-헥사플루오로-2-프로판올 속성
- 녹는점
- −4 °C(lit.)
- 끓는 점
- 59 °C(lit.)
- 밀도
- 1.596 g/mL at 25 °C(lit.)
- 증기압
- 269 hPa (30 °C)
- 굴절률
- n
20/D 1.275(lit.)
- 인화점
- 4,4°C
- 저장 조건
- Store below +30°C.
- 용해도
- soluble in Chloroform, Ethyl Acetate
- 산도 계수 (pKa)
- pK1:9.42 (25°C)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 흰색에서 노란색으로
- Specific Gravity
- 1.596
- 수소이온지수(pH)
- 3-4 (H2O)Aqueous solution
- 수용성
- 1000g/L(25℃)
- 최대 파장(λmax)
- 229nm(lit.)
- BRN
- 1841007
- 안정성
- 안정적인. 강산, 강염기, 알칼리 금속과 호환되지 않습니다.
- InChIKey
- BYEAHWXPCBROCE-UHFFFAOYSA-N
- LogP
- 1.5 at 25℃
- 표면장력
- 67.1mN/m at 1g/L and 19.8℃
- CAS 데이터베이스
- 920-66-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | C,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 20/22-34 | ||
안전지침서 | 26-36/37/39-45-27 | ||
유엔번호(UN No.) | UN 2922 8/PG 2 | ||
WGK 독일 | 2 | ||
RTECS 번호 | UB6450000 | ||
F 고인화성물질 | 27 | ||
위험 참고 사항 | Corrosive | ||
TSCA | T | ||
위험 등급 | 8 | ||
포장분류 | II | ||
HS 번호 | 29055910 | ||
독성 | LD50 orally in Rabbit: 1500 mg/kg | ||
기존화학 물질 | KE-18542 |
1,1,1,3,3,3-헥사플루오로-2-프로판올 C화학적 특성, 용도, 생산
화학적 성질
1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is a clear, colorless, oily, combustible liquid. Odor is described as aromatic.용도
1,1,1,3,3,3-Hexafluoro-2-propanol effects the native state of proteins, denaturing them as well as stabilizing the α-helical conformation of unfolded proteins and polypeptides.정의
ChEBI: An organofluorine compound formed by substitution of all the methyl protons in propan-2-ol by fluorine. It is a metabolite of inhalation anesthetic sevoflurane.일반 설명
1,1,1,3,3,3-Hexafluoro-2-propanol is a solution-phase peptide chemistry solvent. This fluorinated polar solvent of high ionizing power facilitates Friedel–Crafts-type reactions, using covalent reagents in the absence of a Lewis acid catalyst. It also enhances the efficiency of rhodium(I)-catalyzed [4+2] intramolecular cycloaddition of ether-tethered alkynyl dienes and [5+2] cycloaddition of alkynyl vinylcyclopropanes. 1,1,1,3,3,3-Hexafluoro-2-propanol clusters catalyzes the epoxidation of cyclooctene and 1-octene with hydrogen peroxide.공기와 물의 반응
Water soluble.반응 프로필
1,1,1,3,3,3-Hexafluoro-2-propanol is incompatible with acids, acid chlorides and oxidizing agents.화재위험
1,1,1,3,3,3-Hexafluoro-2-propanol is probably combustible.잠재적 노출
A specialty solvent for some poly mers; a lavatory reagent.운송 방법
UN1760 Corrosive liquids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material.Purification Methods
Distil it from 3A molecular sieves, retaining the middle fraction. It has been prepared by reduction of hexafluoroacetone in tetrahydrofuran (THF), In this case hexafluoropropanol forms a stable 1:1 complex which distils at 99-100o/760mm (n 25 1.3283), The complex is decomposed by mixing with 20% oleum and distilling in a vacuum, and the distillate is redistilled to give pure hexafluoropropan-2-ol with b 59o/760mm. The 1H NMR shows a doublet at 4.52ppm (JH,H 2Hz). The benzoyl derivative, [10315-85-2] M 272.1, has m 53.9o after crystalllisation from pentane at -50o, and its IR has at 1760cm-1. [Middleton & Lindsey J Am Chem Soc 86 4948 1964, Urry et al. J Org Chem 32 347 1967.] It has very high peptide solubilising properties, alone or with CH2Cl2 [use as a solvent: Narita et al. Bull Chem Soc Jpn 61 281 1988, Biochemistry 29 2639 1990.] It is CORROSIVE, causes severe eye irritation.비 호환성
HFIP is incompatible with acids, acid chlorides, and oxidizing agents.폐기물 처리
May be incinerated. In accor dance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be dis posed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste contain ing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal.1,1,1,3,3,3-헥사플루오로-2-프로판올 준비 용품 및 원자재
원자재
브롬화 시안
2-Propanol, 1,1,1,2,3,3,3-heptafluoro-
2-(트리메틸실록시)펜타플루오로프로펜
Methyl 3,3,3-Trifluoro-2-hydroxy-2-trifluoromethylpropionate
클로로메틸-1,1,1,3,3,3-헥사플루오로이소프로필에테르
포름산페닐
AMMONIUM TRIFLUOROACETATE
헥사클로로아세톤
헥사플루오로아세톤
트리플루오로아세트산 나트륨
준비 용품
1,1,1,3,3,3-헥사플루오로-2-프로판올 공급 업체
글로벌( 691)공급 업체
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Aladdin Scientific | +1-+1(833)-552-7181 |
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Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 |
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Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
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1,1,1,3,3,3-헥사플루오로-2-프로판올 관련 검색:
1-프로판올 이소프로필알코올 리튬 포스포헥사플루오르화 트리아이소프로판올아민 이소프로판올아민 헥사플로로큐밀알콜 디클로로메탄 1,1,1,3,3,3-헥사플루오로-2-프로판올
5-(TERT-BUTYL)-2-IODO-1,3-DIMETHYLBENZENE
1-PHENYL-2-PROPANOL
Hexaethylene glycol
1,1,1,2,2,3-HEXAFLUOROPROPANE
HEXAFLUORO-2-PROPANOL,2H-HEXAFLUORO-2-PROPANOL,HEXAFLUORO-2-PROPYLALCOHOL
2-(4-AMINOPHENYL)-1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL,2-(4-AMINOPHENYL)HEXAFLUORO-2-PROPANOL
2-(Trifluoromethyl)-1,1,1,3,3,3-hexafluoro-2-propanol
1,1,1-TRIFLUORO-2-(TRIFLUOROMETHYL)PENT-4-EN-2-OL
1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL-D2
1,3-BIS(2-HYDROXYHEXAFLUOROISOPROPYL)BENZENE